Nap and melatonin-induced changes in hippocampal activation and their role in verbal memory consolidation
Nap and melatonin-induced changes in hippocampal activation and their role in verbal memory consolidation
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DOI：
10.1111/j.1600-079x.2007.00482.x
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发表时间：
2007-11-01
影响因子：
10.3
通讯作者：
Zisapel, Nava
中科院分区：
文献类型：
--
作者：
Gorfine, Tali;Yeshurun, Yaara;Zisapel, Nava
过夜睡眠有助于巩固记忆;即使是短暂的小睡也能提高记忆力。这种改善与睡眠期间海马体的活动有关。褪黑激素已被证明会影响人类海马体，并诱导大脑激活的“睡眠样”变化。因此，我们进行了两项功能性磁共振成像研究并进行了比较：第一项研究评估了2小时午休与等量清醒对非文字记忆任务（无关词对关联）的影响;第二项研究评估了褪黑激素与安慰剂（两种情况都没有午睡）对类似任务的影响。我们报告说，午睡后相对于清醒，成功检索相关的激活在海马旁减少。在使用褪黑激素而不是安慰剂的觉醒中观察到较小的减少。与此同时，与清醒状态相比，午睡后的非文字记忆回忆有所改善，但与安慰剂相比，清醒状态下的褪黑激素没有改善。我们的研究结果表明，褪黑激素的影响，类似于那些睡眠对海马体中的文字记忆处理，从而表明褪黑激素，像睡眠，可以启动离线塑料变化的基础记忆巩固，他们还表明，伴随的休息没有干扰是必要的，以提高性能。
Overnight sleep contributes to memory consolidation; even a short nap improves memory performance. Such improvement has been linked to hippocampal activity during sleep. Melatonin has been shown to affect the human hippocampus and to induce 'sleep like' changes in brain activation. We therefore conducted and compared two functional magnetic resonance imaging studies: the first study assessed the effect of a 2-hr mid-day nap versus an equal amount of wakefulness on a verbal memory task (unrelated word pair association); the second assessed the effect of melatonin versus placebo (both conditions without nap) on a similar task. We report that following a nap relative to wakefulness, successful retrieval-related activation in the parahippocampus is decreased. A smaller decrease is seen in wakefulness with melatonin but not placebo. In parallel, an improvement in verbal memory recall was found after a nap compared with wakefulness but not with melatonin during wakefulness compared with placebo. Our findings demonstrate effects of melatonin that resemble those of sleep on verbal memory processing in the hippocampus thus suggesting that melatonin, like sleep, can initiate offline plastic changes underlying memory consolidation; they also suggest that concomitant rest without interferences is necessary for enhanced performance.