Relationship of carotid intima-media thickness, pulse wave velocity, and ankle brachial index to the severity of coronary artery atherosclerosis
Relationship of carotid intima-media thickness, pulse wave velocity, and ankle brachial index to the severity of coronary artery atherosclerosis
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DOI：
10.1002/clc.4960271110
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发表时间：
2004-11-01
影响因子：
2.7
通讯作者：
Yano, K
中科院分区：
文献类型：
--
作者：
Matsushima, Y;Kawano, H;Yano, K
背景：颈动脉内膜中层厚度 (IMT)、脉搏波速度 (PWV) 和踝肱指数 (ABI) 是广泛用于评估动脉粥样硬化的无创方法。假设：本研究的目的是确定颈动脉 IMT、PWV 和 ABI 与冠心病 (CAD) 严重程度（以 Gensini 评分表示）以及冠状动脉危险因素的存在之间的关系。方法：我们检查连续 205 名临床怀疑患有 CAD 并计划接受冠状动脉造影的患者（平均年龄 65 +/- 12 岁）。所有受试者在接受冠状动脉造影前均测量颈动脉内膜中层厚度、臂踝脉搏波速度（baPWV）和ABI。结果：在205名患者中，124名患者因主冠状动脉存在> 50%狭窄而被诊断为CAD，其余81名患者没有患有CAD。颈动脉 IMT 与 Gensini 评分之间存在相对较好的相关性（R = 0.411，p < 0.0001），而 baPWV 与 Gensini 评分的相关性较弱（R = 0.2033 p = 0.0035），而 ABI 与之不相关。多元回归分析显示，Gensini 评分与年龄、男性和颈动脉 IMT 显着且独立相关。结论：在三种无创方法中，颈动脉 IMT 可能比 baPWV 或 ABI 更有助于确定冠状动脉粥样硬化。
Background: Carotid intima-media thickness (IMT), pulse wave velocity (PWV), and the ankle brachial index (ABI) are widely used noninvasive modalities for evaluating atherosclerosis.Hypothesis: The aim of this study was to determine the relationship of carotid IMT, PWV, and ABI with the severity of coronary artery disease (CAD), expressed as the Gensini score, and the presence of coronary risk factors.Methods: We examined 205 consecutive patients (mean age 65 +/- 12 years) who were clinically suspected of having CAD and were scheduled to undergo coronary angiography. Carotid intima-media thickness, brachial-ankle PWV (baPWV), and ABI were measured in all subjects before they underwent coronary angiography.Results: Of the 205 patients, 124 patients were diagnosed as having CAD based on the presence of > 50% stenosis in a major coronary artery, the remaining 81 patients did not have CAD. A relatively good correlation was obtained between carotid IMT and the Gensini score (R = 0.411, p < 0.0001), whereas baPWV correlated only weakly with the Gensini score (R = 0.2033 p = 0.0035), and ABI did not correlate with it. A multiple regression analysis revealed that the Gensini score correlated significantly and independently with age, male gender, and carotid IMT.Conclusions: Of the three noninvasive methods, carotid IMT may be more useful for determining coronary artery atherosclerosis than baPWV or ABI.