Oral sulfonylurea agents suppress hepatic glucose production in non-insulin-dependent diabetic individuals.
Oral sulfonylurea agents suppress hepatic glucose production in non-insulin-dependent diabetic individuals.
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发表时间：
1984
期刊：
影响因子：
16.2
通讯作者：
R. DeFronzo;D. Simonson
中科院分区：
文献类型：
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作者：
R. DeFronzo;D. Simonson
在本文中，我们回顾了有关口服磺酰脲类药物对糖代谢的作用机制的文献。此外，我们报告了我们的研究结果，格列本脲在10名非胰岛素依赖型糖尿病患者的影响。治疗前，空腹血糖浓度平均为198 +/- 19 mg/dl，口服葡萄糖耐量试验（OGTT）明显异常。格列本脲治疗3个月后，空腹血糖下降至141 +/- 16 mg/dl（P <0.01，与普瑞本脲相比），OGTT（绝对血糖浓度）改善（P <0.001）。然而，增量增加（即，在OGTT期间血浆葡萄糖的浓度（高于基础值）没有显著改变。在吸收后状态下，空腹血浆葡萄糖浓度仅由两个因素决定：（1）葡萄糖进入体内的速率，其基本上等于肝葡萄糖产生（HGP）的速率;和（2）葡萄糖从体内清除的速率或葡萄糖清除率。在基础状态下，与年龄匹配的对照组相比，HGP略有增加，平均为2.35 +/- 0.28 mg/kg X min。格列本脲治疗3个月后，HGP降至1.72 +/- 0.18 mg/kg X min（P <0.01），HPG的降低与空腹血糖的降低密切相关（r = 0.85，P <0.005）。与对照组相比，非胰岛素依赖型糖尿病患者的基础葡萄糖清除率降低（1.22 +/- 0.04 vs. 2.32 +/- 0.03 ml/kg X min，P <0.001），但格列本脲治疗后无变化（1.25 +/- 0.10）。（250字处删节）
In the present paper we have reviewed the literature concerning the mechanisms of action of the oral sulfonylurea agents on glucose metabolism. In addition, we report our results examining the effect of glyburide in 10 non-insulin-dependent diabetic patients. Before therapy the fasting glucose concentration averaged 198 +/- 19 mg/dl and the oral glucose tolerance test (OGTT) was markedly abnormal. Following 3 mo of glyburide therapy, the fasting glucose had declined to 141 +/- 16 mg/dl (P less than 0.01 vs. preglyburide) and the OGTT (absolute plasma glucose concentration) was improved (P less than 0.001). However, the incremental increase (i.e., above basal) in plasma glucose during the OGTT was not significantly altered. In the postabsorptive state the fasting plasma glucose concentration is determined by only two factors: (1) the rate of glucose entry into the body, which is essentially equal to the rate of hepatic glucose production (HGP) and (2) the rate of glucose removal from the body or the glucose clearance. In the basal state HGP was slightly increased compared to age-matched controls and averaged 2.35 +/- 0.28 mg/kg X min. Following 3 mo of glyburide, HGP decreased to 1.72 +/- 0.18 mg/kg X min (P less than 0.01) and the decrease in HPG was strongly correlated with the decrease in fasting glucose (r = 0.85, P less than 0.005). Basal glucose clearance in non-insulin-dependent diabetes was reduced compared to controls (1.22 +/- 0.04 vs. 2.32 +/- 0.03 ml/kg X min, P less than 0.001) but did not change after glyburide (1.25 +/- 0.10).(ABSTRACT TRUNCATED AT 250 WORDS)