Anti-edema effect of epigallocatechin gallate on spinal cord injury in rats
Anti-edema effect of epigallocatechin gallate on spinal cord injury in rats
复制标题
表没食子儿茶素没食子酸酯对大鼠脊髓损伤的抗水肿作用
DOI：
10.1016/j.brainres.2013.06.009
复制
发表时间：
2013-08-21
期刊：
影响因子：
2.9
通讯作者：
Xiong, Xiao-chuan
中科院分区：
文献类型：
--
作者：
Ge, Rui;Zhu, Yue;Xiong, Xiao-chuan
近年来研究表明表没食子儿茶素没食子酸酯（epigallocatechin gallate，EGCG）对脊髓损伤具有神经保护作用。本研究旨在探讨EGCG对大鼠脊髓损伤后的抗水肿作用。EGCG（100 mg/kg，i.p.）在SCI后立即给予大鼠。结果表明，EGCG（100 mg/kg）能显著降低脊髓含水量。另外，EGCG（100 mg/kg）在伤后24、48和72 h均能显著降低AQP 4和GFAP的表达，而在伤后12 h则无此作用。EGCG（100 mg/kg）处理引起的AQP 4和GFAP蛋白的变化伴随着脊髓水肿的减轻。结果表明，EGCG（100 mg/kg）可减轻脊髓损伤后的水肿，其机制可能与下调脊髓损伤后AQP 4和GFAP蛋白的表达有关。(C)2013 Elsevier B. V.保留所有权利。
Recent studies indicated that epigallocatechin gallate (EGCG) had neuroprotective effects on spinal cord injury (SCI). The current study was performed to determine the anti-edema effect of EGCG after SCI in rats. EGCG (100 mg/kg, i.p.) was administered to rats immediately following SCI. It was found that EGCG (100 mg/kg) could significantly reduce spinal cord water content. In addition, EGCG (100 mg/kg) significantly reduced the expression of aquaporin-4 (AQP4) and glial fibrillary acidic protein (GFAP) level at 24, 48 and 72 h after injury, but it did not have this effect at 12 h after injury. The changes of AQP4 and GFAP protein induced by EGCG (100 mg/kg) treatment were accompanied by a reduction of spinal cord edema. Our results indicated that EGCG (100 mg/kg) could reduce spinal cord edema after SCI, which could be correlated with the down-regulation the expression of AQP4 and GFAP protein level after SCI. (C) 2013 Elsevier B.V. All rights reserved.