The role of endocytic Rab GTPases in regulation of growth factor signaling and the migration and invasion of tumor cells.
The role of endocytic Rab GTPases in regulation of growth factor signaling and the migration and invasion of tumor cells.
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DOI：
10.1080/21541248.2015.1050152
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发表时间：
2015-01-01
期刊：
影响因子：
--
通讯作者：
Barbieri, M A
中科院分区：
文献类型：
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作者：
Porther, N;Barbieri, M A
转移的病理特征是不受控制的细胞侵袭、增殖、迁移和血管生成。这是一个多步骤的过程，包括调节膜通透性和侵袭、细胞扩散、细胞迁移和细胞外基质增殖、细胞粘附分子和相互作用的增加、细胞附着的减少和诱导的生存信号以及营养供应（血管）的传播。在癌症中，如果没有一系列同步事件，实体瘤就无法扩张和扩散。细胞粘附受体分子（例如整合素、钙粘蛋白-连环蛋白）和蛋白酶表达的变化与肿瘤侵袭和转移有关。还确定配体-生长因子受体相互作用与通过内吞途径的癌症发展和转移有关。具体而言，生长因子（包括 IGF-1 和 IGF-2 治疗）与大多数（如果不是全部）转移特征相关。在这篇综述中，我们将重新审视关于癌症转移最重要标志之一的一些关键发现：细胞迁移和细胞侵袭以及内吞途径在介导这种现象中的作用。
Metastasis is characterized pathologically by uncontrolled cell invasion, proliferation, migration and angiogenesis. It is a multistep process that encompasses the modulation of membrane permeability and invasion, cell spreading, cell migration and proliferation of the extracellular matrix, increase in cell adhesion molecules and interaction, decrease in cell attachment and induced survival signals and propagation of nutrient supplies (blood vessels). In cancer, a solid tumor cannot expand and spread without a series of synchronized events. Changes in cell adhesion receptor molecules (e.g., integrins, cadherin-catenins) and protease expressions have been linked to tumor invasion and metastasis. It has also been determined that ligand-growth factor receptor interactions have been associated with cancer development and metastasis via the endocytic pathway. Specifically, growth factors, which include IGF-1 and IGF-2 therapy, have been associated with most if not all of the features of metastasis. In this review, we will revisit some of the key findings on perhaps one of the most important hallmarks of cancer metastasis: cell migration and cell invasion and the role of the endocytic pathway in mediating this phenomenon.