Exposure to perfluoroalkyl substances (PFAS) and associations with thyroid parameters in First Nation children and youth from Quebec
Exposure to perfluoroalkyl substances (PFAS) and associations with thyroid parameters in First Nation children and youth from Quebec
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DOI：
10.1016/j.envint.2019.04.029
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发表时间：
2019-07-01
影响因子：
11.8
通讯作者：
Lemire, Melanie
中科院分区：
文献类型：
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作者：
Caron-Beaudoin, Elyse;Ayotte, Pierre;Lemire, Melanie
背景：全氟烷基物质（PFASs）存在于几种消费品中。儿童暴露于PFAS与甲状腺激素的改变有关，甲状腺激素在脑功能中起着关键作用。目的：2015年，198名儿童和青少年（3- 19岁）被招募作为试点项目“青年、环境与健康”（JES！YEH！），这是与魁北克的四个第一民族社区合作实现的。我们的目的是评估PFASs的血清浓度与促甲状腺激素（TSH），游离甲状腺素（T4）和甲状腺球蛋白的浓度，同时调整相关confounders.Methods：PFASs（PFOS，PFOA，PFHxS，PFNA），2，2 '，4，4'-四溴二苯醚（PBDE-47）的甲状腺参数（TSH，游离T4，和甲状腺球蛋白）测定186名参与者的血清样本。在尿样中测量碘、肌酐和可替宁。PFAS的血清水平进行了比较，在一般加拿大人口和其他地方的测量。多元回归分析，以确定PFASs和TSH，游离T4和甲状腺球蛋白之间的关联。然而，Anishinabe社区12至19岁参与者的PFNA浓度比加拿大健康措施调查中测量的浓度高出三倍（2009-2011年）（几何平均值：分别为3.01 μ g/L和0.71 μ g/L），在6至11岁的Anishinabe参与者中特别高（GM：9.44 μ g/L）。少数参与者的TSH、游离T4和甲状腺球蛋白水平超出了特定年龄的儿科范围。校正相关协变量和其他污染物后，PFNA血清浓度与游离T4水平呈正相关（校正后β = 0.36; p = 0.0014），但与TSH和甲状腺球蛋白水平无关。其他PFAS和甲状腺激素parameters.Conclusion之间没有观察到任何关联：这个试点项目揭示了最高的PFNA在儿童中的报告，直到今天，并建议PFNA作为一种内分泌干扰物的影响，突出调查的来源和影响不成比例地暴露于新出现的污染物在一些土著社区和禁止所有PFAS在国际范围内的重要性。
Background: Perfluoroalkyl substances (PFASs) are found in several consumer goods. Exposure to PFASs in children has been associated with alteration in thyroid hormones, which have critical roles in brain function.Objective: In 2015, 198 children and youth (3-19y) were recruited as part of the pilot project Jeunes, Environnement et Sante/Youth, Environment and Health (JES!-YEH!), realized in collaboration with four First Nation communities in Quebec. We aimed to evaluate serum concentrations of PFASs in relation to concentrations of thyroid-stimulating hormone (TSH), free thyroxine (T4) and thyroglobulin while adjusting for relevant confounders.Methods: PFASs (PFOS, PFOA, PFHxS, PFNA), 2,2',4,4'-Tetrabromodiphenyl ether (PBDE-47) thyroid parameters (TSH, free T4, and thyroglobulin) were measured in serum samples of 186 participants. Iodine, creatinine, and cotinine were measured in urine samples. Serum levels of PFASs were compared to those measured in the general Canadian population and elsewhere. Multivariate regression analyses were performed to determine associations between PFASs and TSH, free T4 and thyroglobulin.Results: PFOS, PFOA and PFHxS serum concentrations were low. However, PFNA concentrations among participants aged 12 to 19 years old from Anishinabe communities were three times higher than those measured in the Canadian Health Measures Survey (2009-2011) for the same age group (Geometric Means: 3.01 mu g/L and 0.71 mu g/L, respectively) and were particularly higher in the Anishinabe participants aged 6 to 11 years old (GM: 9.44 mu g/L). Few participants had levels of TSH, free T4, and thyroglobulin outside age-specific paediatric ranges. When adjusted for relevant covariates and other contaminants, PFNA serum concentrations were positively associated with free T4 levels (Adjusted beta = 0.36; p = 0.0014), but not with TSH and thyroglobulin levels. No association was observed between the other PFAS and thyroid hormones parameters.Conclusion: This pilot project reveals among the highest exposure to PFNA in children reported until today, and suggests effects of PFNA as an endocrine disruptor, highlighting the importance of investigating the sources and effects of disproportionate exposure to emerging contaminants in some indigenous communities and ban all PFAS at the international scale.