Immune modulation therapy in the management of bortezomib-induced peripheral neuropathy
Immune modulation therapy in the management of bortezomib-induced peripheral neuropathy
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DOI：
10.1186/2162-3619-1-20
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Kang, Yubin
中科院分区：
文献类型：
--
作者：
Jeter, Ashley;Kang, Yubin
周围神经病变（PN）是硼替佐米治疗最常见的副作用之一。大多数硼替佐米相关的 PN 是轻至中度的感觉神经病变，在减少剂量或停药后可逆转。然而，偶尔硼替佐米引起的神经病变可能很严重并影响运动和/或自主神经，并且可能是由免疫过程介导的。免疫调节疗法在硼替佐米诱导的 PN 治疗中的作用尚未明确。在这里，我们报道了一例硼替佐米引起的严重 PN，对血浆置换和类固醇治疗反应良好。
Peripheral neuropathy (PN) is one of the most common side effects of bortezomib therapy. The majority of bortezomib-related PN is a sensory neuropathy of mild to moderate degree, and is reversible after dose reduction or discontinuation. However, occasionally bortezomib-induced neuropathy can be severe and affects motor and/or autonomic nerves, and may be mediated by immune process. The role of immune modulation therapy in the management of bortezomib-induced PN was not well established. Here, we reported a case of bortezomib-induced severe PN that responded well to plasma exchange and steroid treatment.