Decreased ventral anterior cingulate cortex activity is associated with reduced social pain during emotional support
Decreased ventral anterior cingulate cortex activity is associated with reduced social pain during emotional support
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DOI：
10.1080/17470910902955884
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发表时间：
2009-09
影响因子：
2
通讯作者：
K. Onoda;Y. Okamoto;Ken'ichiro Nakashima;H. Nittono;Mitsuhiro Ura;S. Yamawaki
中科院分区：
文献类型：
--
作者：
K. Onoda;Y. Okamoto;Ken'ichiro Nakashima;H. Nittono;Mitsuhiro Ura;S. Yamawaki
人们在被排斥时会感到心理上的痛苦，而这种痛苦在得到情感支持时往往会减轻。因此，一种特定的神经机制很可能是社会排斥检测的基础。同样，特定的神经机制可能是情感支持有益效果的基础。虽然神经影像学研究人员最近研究了社会性疼痛的神经基础，但目前还没有关于前扣带皮层（ACC）的哪一部分参与社会性疼痛的感知和调节的共识。我们假设，那些与社交痛苦相关的大脑区域的活动与情感支持引起的社交痛苦的减少有关。为了检验情感支持对由排斥引起的社会痛苦的影响，我们进行了一项功能磁共振成像研究，让参与者玩一个虚拟的投球游戏。参与者最初被纳入，后来被排除在游戏之外。在实验的后半部分，参与者被排除在外，他们收到了情感支持的短信。我们发现，情感支持导致左外侧/内侧前额叶皮层和一些颞叶区域的活动增加。那些经历社交疼痛衰减的个体表现出较低的腹侧ACC和较高的左外侧前额皮质激活。这些结果表明，腹侧ACC是社交疼痛的基础，而情感支持增强了前额叶皮层的活动，这反过来可能导致情感反应减弱。
Abstract People feel psychological pain when they are excluded, and this pain is often attenuated when emotional support is received. It is therefore likely that a specific neural mechanism underlies the detection of social exclusion. Similarly, specific neural mechanisms may underlie the beneficial effects of emotional support. Although neuroimaging researchers have recently examined the neural basis of social pain, there is presently no agreement as to which part of the anterior cingulate cortex (ACC) is involved in the perception and modulation of social pain. We hypothesized that activity in those brain regions that are associated with social pain would be correlated with decrements in social pain induced by emotional support. To examine the effects of emotional support on social pain caused by exclusion, we conducted an fMRI study in which participants played a virtual ball-tossing game. Participants were initially included and later excluded from the game. In the latter half of the session from which participants were excluded, participants received emotionally supportive text messages. We found that emotional support led to increased activity in the left lateral/medial prefrontal cortices and some temporal regions. Those individuals who experienced greater attenuation of social pain exhibited lower ventral ACC and higher left lateral prefrontal cortex activation. These results suggest that the ventral ACC underlies social pain, and that emotional support enhances prefrontal cortex activity, which in turn may lead to a weakened affective response.