Exposure to activity-based anorexia impairs contextual learning in weight-restored rats without affecting spatial learning, taste, anxiety, or dietary-fat preference.
Exposure to activity-based anorexia impairs contextual learning in weight-restored rats without affecting spatial learning, taste, anxiety, or dietary-fat preference.
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DOI：
10.1002/eat.22489
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发表时间：
2016-02
期刊：
影响因子：
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通讯作者：
Tamashiro KL
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文献类型：
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作者：
Boersma GJ;Treesukosol Y;Cordner ZA;Kastelein A;Choi P;Moran TH;Tamashiro KL
神经性厌食症（AN）的复发率很高，这表明AN引起的一些改变可能在体重恢复后仍然存在。为了研究AN的后果而不受环境变化的干扰，可以采用基于活动的厌食症（阿坝）的啮齿动物模型。我们推测，在青春期暴露于阿坝可能会对味觉功能，认知和体重恢复后的焦虑行为产生长期影响。为了验证这一假设，我们将青春期雌性大鼠暴露于阿坝（1.5小时食物获取，结合自愿转轮获取），并在体重恢复后将其行为与对照大鼠的行为进行比较。在光照期间进行的一组行为测试中测试大鼠的学习/记忆、焦虑、食物偏好和味觉。我们的数据表明，阿坝暴露导致降低性能在新的物体识别任务，测试上下文学习，而不改变性能在新的地方识别任务或巴恩斯迷宫，这两个任务，测试空间学习。此外，我们没有观察到对蔗糖或奎宁（分别被人类描述为“甜”和“苦”）的无条件舔反应的改变。我们也没有发现在高架十字迷宫或旷场测试中焦虑样行为的改变。最后，对高脂肪饮食的偏好没有改变。总的来说，我们的数据表明，阿坝暴露在青春期损害背景学习在成年期不改变空间倾斜，口味，焦虑，或脂肪偏好。
Relapse rates are high amongst cases of Anorexia Nervosa (AN) suggesting that some alterations induced by AN may remain after weight restoration. To study the consequences of AN without confounds of environmental variability, a rodent model of activity based anorexia (ABA) can be employed. We hypothesized that exposure to ABA during adolescence may have long-term consequences in taste function, cognition, and anxiety-like behavior after weight restoration. To test this hypothesis we exposed adolescent female rats to ABA (1.5 hrs food access, combined with voluntary running wheel access) and compared their behavior to that of control rats after weight restoration was achieved. The rats were tested for learning /memory, anxiety, food preference and taste in a set of behavioral tests performed during the light period. Our data show that ABA exposure leads to reduced performance during the novel object recognition task, a test for contextual learning, without altering performance in the novel place recognition task or the Barnes maze, both tasks that test spatial learning. Furthermore, we do not observe alterations in unconditioned lick responses to sucrose nor quinine (described by humans as “sweet” and “bitter” respectively). Nor did we find alterations in anxiety-like behavior during an elevated plus maze or an open field test. Finally, preference for a diet high in fat was not altered. Overall our data suggest that ABA exposure during adolescence impairs contextual learning in adulthood without altering spatial leaning, taste, anxiety, or fat preference.