Stimulus-Artifact Elimination in a Multi-Electrode System
Stimulus-Artifact Elimination in a Multi-Electrode System
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DOI：
10.1109/tbcas.2008.918285
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发表时间：
2008-03-01
影响因子：
5.1
通讯作者：
DeWeerth, Stephen P.
中科院分区：
文献类型：
--
作者：
Brown, Edgar A.;Ross, James D.;DeWeerth, Stephen P.
为了充分利用当前和未来几代多电极阵列提供的记录能力，需要一些消除刺激方案产生的残留电荷和后续伪影的手段。定制电子设备可以用于实现这些目标，并且通过使其可扩展，可以在实验中访问大量电极。在这项工作中，我们提出了一个系统，建立在一个自定义的16通道IC，可以刺激和记录，在3毫秒内的刺激，在刺激通道，并在500亩的相邻通道。这种有效性是通过新颖的反馈方案直接对电极放电，并通过塑造这种反馈来优化电极行为来实现的。我们表征的不同功能的系统，使这种性能成为可能，并提出生物数据，显示系统在操作中。为了使这种特性，我们提出了一个框架，用于测量，分类和理解的刺激伪影的多个来源。该框架有利于比较伪影消除方法，并使未来的伪影研究。
To fully exploit the recording capabilities provided by current and future generations of multi-electrode arrays, some means to eliminate the residual charge and subsequent artifacts generated by stimulation protocols is required. Custom electronics can be used to achieve such goals, and by making them scalable, a large number of electrodes can be accessed in an experiment. In this work, we present a system built around a custom 16-channel IC that can stimulate and record, within 3 ms of the stimulus, on the stimulating channel, and within 500 mu s on adjacent channels. This effectiveness is achieved by directly discharging the electrode through a novel feedback scheme, and by shaping such feedback to optimize electrode behavior. We characterize the different features of the system that makes such performance possible and present biological data that show the system in operation. To enable this characterization, we present a framework for measuring, classifying, and understanding the multiple sources of stimulus artifacts. This framework facilitates comparisons between artifact elimination methodologies and enables future artifact studies.