Management of patients with biliary atresia in France:: Results of a decentralized policy 1986-2002
Management of patients with biliary atresia in France:: Results of a decentralized policy 1986-2002
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DOI：
10.1002/hep.21219
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发表时间：
2006-07-01
期刊：
影响因子：
13.5
通讯作者：
Chardot, Christophe
中科院分区：
文献类型：
--
作者：
Serinet, Marie-Odile;Broue, Pierre;Chardot, Christophe
这项研究分析了法国胆道闭锁（BA）分散管理的结果，该国自 1997 年以来一直在推动改善中心之间的合作。结果与英格兰和威尔士的结果进行了比较，这些地区的 BA 患者自 1999 年以来一直集中在三个指定中心。根据出生日期，BA 患者分为两组：A 组，1986 年至 1996 年出生的患者，有 472 名患者；A 组，1986 年至 1996 年出生的患者，有 472 名患者；第 13 组患者出生于 1997 年至 2002 年，共有 271 名患者。根据Kaplan-Meier法计算存活率，并使用对数秩检验和Cox模型进行比较。 A 组和 B 组中 BA 患者的四年总生存率分别为 73.6% (95% CI 69.5%-77.7%) 和 87.1% (CI 82.6%-91.6%) (P
This study analyzed the results of the decentralized management of biliary atresia (BA) in France, where an improved collaboration between centers has been promoted since 1997. Results were compared to those obtained in England and Wales, where BA patients have been centralized in three designated centers since 1999. According to their birth dates, BA patients were divided into two cohorts: cohort A, with patients born between 1986 and 1996, had 472 patients; and cohort 13, with patients born between 1997 and 2002, had 271 patients. Survival rates were calculated according to the Kaplan-Meier method and compared by using the log rank test and the Cox model. Four-year overall BA patient survival was 73.6% (95% CI 69.5%-77.7%) and 87.1% (CI 82.6%-91.6%) in cohorts A and B, respectively (P