A preneoplastic stage in the spontaneous neoplastic transformation of syrian hamster embryo cells in culture.
A preneoplastic stage in the spontaneous neoplastic transformation of syrian hamster embryo cells in culture.
复制标题
培养中的叙利亚仓鼠胚胎细胞自发肿瘤转化的肿瘤前阶段。
作者：
J. Barrett
培养中的叙利亚仓鼠胚胎细胞的自发肿瘤转化至少分两个步骤进行。中间阶段以肿瘤前期的非整倍体细胞系为代表。这些细胞在许多特性上与二倍体细胞不同，包括它们在附着于基质的情况下注射时在体内变成肿瘤的能力。这些结果支持体外细胞肿瘤转化的多步骤过程，并警告不要将非整倍体细胞系视为“正常”细胞。
Spontaneous neoplastic transformation of Syrian hamster embryo cells in culture occurs in at least two steps. An intermediate stage is represented by an aneuploid cell line which is preneoplastic. These cells differ from the diploid cells by a number of properties, including their ability to become neoplastic in vivo when injected while attached to a substrate. These results support a multistep process for neoplastic transformation of cells in vitro and caution against considering aneuploid cell lines as "normal" cells.