No peroxisome is an island - Peroxisome contact sites.
No peroxisome is an island - Peroxisome contact sites.
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DOI：
10.1016/j.bbamcr.2015.09.016
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发表时间：
2016-05
期刊：
影响因子：
--
通讯作者：
Zalckvar E
中科院分区：
文献类型：
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作者：
Shai N;Schuldiner M;Zalckvar E
为了优化其多种细胞功能，过氧化物酶体必须与周围的细胞器协作和沟通。细胞器之间的一种常见通信方式是通过物理膜接触位点，两个细胞器的膜被拴在一起，促进小分子交换和细胞内信号传导。此外，接触位点对控制代谢、细胞器运输、遗传和分裂等过程也很重要。过氧化物酶体的各种细胞活动是如何依赖于接触位点的，直到最近人们才开始认识和探索过氧化物酶体的交流程度，它们的接触位点和功能的特征较少。本文综述了已鉴定的过氧化物酶体接触位点、它们的系链复合物及其潜在的生理作用。此外，我们强调了一些初步的证据，存在于未开发的过氧化物酶体接触地点。
In order to optimize their multiple cellular functions, peroxisomes must collaborate and communicate with the surrounding organelles. A common way of communication between organelles is through physical membrane contact sites where membranes of two organelles are tethered, facilitating exchange of small molecules and intracellular signaling. In addition contact sites are important for controlling processes such as metabolism, organelle trafficking, inheritance and division. How peroxisomes rely on contact sites for their various cellular activities is only recently starting to be appreciated and explored and the extent of peroxisomal communication, their contact sites and their functions are less characterized. In this review we summarize the identified peroxisomal contact sites, their tethering complexes and their potential physiological roles. Additionally, we highlight some of the preliminary evidence that exists in the field for unexplored peroxisomal contact sites.