Counterpropagating Gradients of Antibacterial and Antifouling Polymer Brushes
Counterpropagating Gradients of Antibacterial and Antifouling Polymer Brushes
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DOI：
10.1021/acs.biomac.1c01386
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发表时间：
2021-12-14
影响因子：
6.2
通讯作者：
Genzer, Jan
中科院分区：
文献类型：
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作者：
Ko, Yeongun;Truong, Vi Khanh;Genzer, Jan
报道了聚(2-二甲氨基乙基)甲基丙烯酸酯(PDMAEMA)刷子中反向传播密度梯度的形成，该刷具有空间变化的季胺化和贝塔化单元。从具有恒定接枝密度和聚合度的PDMAEMA刷子开始，我们首先通过与碘甲烷的定向蒸气反应产生季节化单元的密度梯度。然后，未反应的DMAEMA单元通过1，3-丙磺内酯的气相甜菜碱化。PDMAEMA与1，3-丙磺酸内酯的气相反应消除了液相改性过程中存在的副产物的形成。我们使用季胺化和贝塔化PDMAEMA刷子的反向传播密度梯度进行抗菌和防污垢研究。完全季铵化和贝塔宁化的刷子具有抗菌和防污性能。含有12%季铵盐化单元和85%倍他敏化单元的样品同时起到抗菌和防污的作用。
We report on the formation of counterpropagating density gradients in poly([2-dimethylaminoethyl] methacrylate) (PDMAEMA) brushes featuring spatially varying quaternized and betainized units. Starting with PDMAEMA brushes with constant grafting density and degree of polymerization, we first generate a density gradient of quaternized units by directional vapor reaction involving methyl iodide. The unreacted DMAEMA units are then betainized through gaseous-phase betainization with 1,3-propanesultone. The gas reaction of PDMAEMA with 1,3-propanesultone eliminates the formation of byproducts present during the liquid-phase modification. We use the counterpropagating density gradients of quaternized and betainized PDMAEMA brushes in antibacterial and antifouling studies. Completely quaternized and betainized brushes exhibit antibacterial and antifouling behaviors. Samples containing 12% of quaternized and 85% of betainized units act simultaneously as antibacterial and antifouling surfaces.