Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn.
Identifying functional populations among the interneurons in laminae I-III of the spinal dorsal horn.
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DOI：
10.1177/1744806917693003
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发表时间：
2017-01
期刊：
影响因子：
3.3
通讯作者：
Todd AJ
中科院分区：
文献类型：
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作者：
Todd AJ
脊髓背角接受初级传入轴突的输入，初级传入轴突在不同的板层以一种特定的方式终止。传入的体感信息通过涉及兴奋性和抑制性中间神经元的复杂突触电路进行处理，然后通过投射神经元传输到大脑进行意识感知。背角很重要，首先是因为这一区域的变化导致了慢性疼痛状态，其次是因为它包含了开发新的疼痛治疗方法的潜在靶点。然而，目前我们对该区域内的神经元回路的了解有限，这在很大程度上是因为很难确定兴奋性和抑制性中间神经元之间的功能群体。最近发现了特定的神经化学定义的中间神经元群体，加上在体内改变神经元功能的分子遗传学技术的发展，导致我们对脊髓水平的体感加工的理解有了显著的提高。
The spinal dorsal horn receives input from primary afferent axons, which terminate in a modality-specific fashion in different laminae. The incoming somatosensory information is processed through complex synaptic circuits involving excitatory and inhibitory interneurons, before being transmitted to the brain via projection neurons for conscious perception. The dorsal horn is important, firstly because changes in this region contribute to chronic pain states, and secondly because it contains potential targets for the development of new treatments for pain. However, at present, we have only a limited understanding of the neuronal circuitry within this region, and this is largely because of the difficulty in defining functional populations among the excitatory and inhibitory interneurons. The recent discovery of specific neurochemically defined interneuron populations, together with the development of molecular genetic techniques for altering neuronal function in vivo, are resulting in a dramatic improvement in our understanding of somatosensory processing at the spinal level.