Role of IL-6 in cytokine-induced sickness behavior:: a study with IL-6 deficient mice
Role of IL-6 in cytokine-induced sickness behavior:: a study with IL-6 deficient mice
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DOI：
10.1016/s0031-9384(00)00269-9
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发表时间：
2000-08-01
影响因子：
2.9
通讯作者：
Dantzer, R
中科院分区：
文献类型：
--
作者：
Bluthé, RM;Michaud, B;Dantzer, R
白介素 6 (IL-6) 是在细胞因子诱导剂脂多糖 (LPS) 和 IL-1 的作用下合成和释放的，并充当内源性致热原。对小鼠全身注射 LPS 和 IL-1 会诱发疾病迹象，包括社交探索减少、不动和体重减轻。为了评估 IL-6 在诱导疾病行为中的作用，使用了雄性 IL-6 缺陷小鼠（IL-6 -/-，Balb/cAn 遗传背景）并与 IL-6 +/+ 同窝小鼠进行比较。腹腔注射LPS（2.5μg/小鼠）和IL-1β（1.0μg/小鼠）对IL-6+/+小鼠的行为和体重变化的抑制作用比IL-6-/-小鼠更明显。当将 LPS（5 ng/小鼠）和 IL-1 beta（1 ng/小鼠）注射到小鼠大脑侧脑室（静脉注射）时，观察到相同的差异。这些结果表明，外周和/或中枢神经系统释放的IL-6在对LPS和IL-1的行为反应中发挥作用。 (C) 2000 爱思唯尔科学公司。版权所有。
Interleukin-6 (IL-6) is synthesized and released in response to the cytokine inducer lipopolysaccharide (LPS) and IL-1, and acts as an endogenous pyrogen. Systemic administration of LPS and IL-1 to mice induces signs of sickness, including reduction of social exploration, immobility and body weight loss. To assess the role of IL-6 in the induction of sickness behavior, male IL-6-deficient mice (IL-6 -/-, Balb/cAn genetic background) were used and compared to IL-6 +/+ littermates. The depressing effects of intraperitoneal LPS (2.5 mu g/ mouse) and IL-1 beta (1.0 mu g/mouse) on behavior and change in body weight were more marked in IL-6 +/+ than in IL-6 -/- mice. The same difference was observed when mice were injected with LPS (5 ng/mouse) and IL-1 beta (1 ng/mouse) into the lateral ventricle of the brain (i.c.v.). These results show that IL-6 released at the periphery and/or in the central nervous system plays a role in the behavioral response to LPS and IL-1. (C) 2000 Elsevier Science inc. All rights reserved.