3D-neuronavigation in vivo through a patient's brain during a spontaneous migraine headache.
3D-neuronavigation in vivo through a patient's brain during a spontaneous migraine headache.
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DOI：
10.3791/50682
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发表时间：
2014-06-02
期刊：
影响因子：
--
通讯作者：
Zubieta JK
中科院分区：
文献类型：
--
作者：
DaSilva AF;Nascimento TD;Love T;DosSantos MF;Martikainen IK;Cummiford CM;DeBoer M;Lucas SR;Bender MA;Koeppe RA;Hall T;Petty S;Maslowski E;Smith YR;Zubieta JK
越来越多的研究，主要来自基于MRI的研究，表明偏头痛似乎发生，并可能持续，由于中枢神经系统中特定神经过程的改变。然而，缺乏关于这些变化的分子影响的信息，特别是在偏头痛期间对内源性阿片系统的影响，并且从未通过这些变化进行神经导航。本研究旨在使用新型3D沉浸式和交互式神经导航（3D-IIN）方法研究体内偏头痛发作期间大脑中的内源性μ-阿片类药物传递。这可以说是与疼痛调节相关的最中枢神经机制之一，影响疼痛体验和镇痛的多个要素。一名36岁女性，患有偏头痛10年，在典型头痛（发作期）和非头痛（发作间期）偏头痛阶段使用正电子发射断层扫描（PET）和选择性放射性示踪剂[11 C]卡芬太尼进行扫描，这使我们能够测量大脑中的μ-阿片受体可用性（不可替代结合电位- μOR BPND）。短寿命放射性示踪剂是由位于成像设施附近的校园回旋加速器和化学合成装置产生的。发作间期和发作期的PET扫描都安排在患者月经周期的卵泡中期和晚期。在PET发作期间，她的自发性头痛发作达到严重程度;扫描结束时进展为恶心和呕吐。在发作期，内源性μ-阿片系统的疼痛调节区域（包括扣带皮层、丘脑核（NAcc）、丘脑（塔尔）和导水管周围灰质（PAG））的μOR BPND减少;表明μ OR已经被持续疼痛反应释放的内源性阿片类占据。据我们所知，这是第一次使用新型3D方法对偏头痛发作期间µOR BPND的变化进行神经导航。该方法允许在实际患者的神经成像数据集中对偏头痛发作进行交互式研究和教育探索。
A growing body of research, generated primarily from MRI-based studies, shows that migraine appears to occur, and possibly endure, due to the alteration of specific neural processes in the central nervous system. However, information is lacking on the molecular impact of these changes, especially on the endogenous opioid system during migraine headaches, and neuronavigation through these changes has never been done. This study aimed to investigate, using a novel 3D immersive and interactive neuronavigation (3D-IIN) approach, the endogenous µ-opioid transmission in the brain during a migraine headache attack in vivo. This is arguably one of the most central neuromechanisms associated with pain regulation, affecting multiple elements of the pain experience and analgesia. A 36 year-old female, who has been suffering with migraine for 10 years, was scanned in the typical headache (ictal) and nonheadache (interictal) migraine phases using Positron Emission Tomography (PET) with the selective radiotracer [11C]carfentanil, which allowed us to measure µ-opioid receptor availability in the brain (non-displaceable binding potential - µOR BPND). The short-life radiotracer was produced by a cyclotron and chemical synthesis apparatus on campus located in close proximity to the imaging facility. Both PET scans, interictal and ictal, were scheduled during separate mid-late follicular phases of the patient's menstrual cycle. During the ictal PET session her spontaneous headache attack reached severe intensity levels; progressing to nausea and vomiting at the end of the scan session. There were reductions in µOR BPND in the pain-modulatory regions of the endogenous µ-opioid system during the ictal phase, including the cingulate cortex, nucleus accumbens (NAcc), thalamus (Thal), and periaqueductal gray matter (PAG); indicating that µORs were already occupied by endogenous opioids released in response to the ongoing pain. To our knowledge, this is the first time that changes in µOR BPND during a migraine headache attack have been neuronavigated using a novel 3D approach. This method allows for interactive research and educational exploration of a migraine attack in an actual patient's neuroimaging dataset.
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影响因子：
14.5
作者：
Afridi, SK;Matharu, MS;Goadsby, PJ
通讯作者：
Goadsby, PJ
影响因子：
9.9
作者：
Cao, Y;Aurora, SK;Welch, KMA
通讯作者：
Welch, KMA
影响因子：
82.9
作者：
WEILLER, C;MAY, A;DIENER, HC
通讯作者：
DIENER, HC
影响因子：
--
作者：
Hu, XH;Markson, LE;Berger, ML
通讯作者：
Berger, ML
影响因子：
7.4
作者：
Menon, S.;Lea, R. A.;Roy, B.;Hanna, M.;Wee, S.;Haupt, L. M.;Griffiths, L. R.
通讯作者：
Griffiths, L. R.