Mitochondrial UCP2 in the central regulation of metabolism
Mitochondrial UCP2 in the central regulation of metabolism
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DOI：
10.1016/j.beem.2014.02.006
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发表时间：
2014-10-01
影响因子：
7.4
通讯作者：
Diano, Sabrina
中科院分区：
文献类型：
--
作者：
Toda, Chitoku;Diano, Sabrina
解偶联蛋白2(UCP2)是一种线粒体负离子载体蛋白，它通过消除线粒体内膜上产生的质子梯度，将氧化磷酸化与ATP合成解偶联。UCP2不仅调节线粒体TP的产生，还调节细胞内被认为是重要的第二信使信号的活性氧物种(ROS)的产生。UCP2在巨噬细胞和胰岛β细胞中的重要性首次被报道。然而，一些研究已经揭示了UCP2在中枢神经系统(CNS)调节包括食物摄取、能量消耗、葡萄糖稳态和奖励行为在内的动态平衡机制中的重要作用。中枢UCP2影响这些过程的机制似乎与突触和线粒体的可塑性有关。在这篇综述中，我们将描述关于中央UCP2的最新发现，并讨论它在中枢调节动态平衡中的作用。(C)爱思唯尔有限公司出版的2014年。
Uncoupling protein 2 (UCP2) is a mitochondrial anion carrier protein, which uncouples the oxidative phosphorylation from ATP production by dissipating the proton gradient generated across the mitochondrial inner membrane. UCP2 regulates not only mitochondrial TP production, but also the generation of reactive oxygen species (ROS), considered important second-messenger signals within the cell. The importance of UCP2 was firstly reported in macrophages and pancreatic beta cells. However, several studies have revealed the important role of UCP2 in the Central Nervous System (CNS) in the regulation of homeostatic mechanisms including food intake, energy expenditure, glucose homeostasis and reward behaviors. The mechanisms by which central UCP2 affect these processes seem to be associated with synaptic and mitochondrial plasticity. In this review, we will describe recent findings on central UCP2 and discuss its role in CNS regulation of homeostasis. (C) 2014 Published by Elsevier Ltd.