Prednisone therapy of membranoproliferative glomerulonephritis in children.
Prednisone therapy of membranoproliferative glomerulonephritis in children.
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泼尼松治疗儿童膜增生性肾小球肾炎。
DOI：
10.1016/s0022-3476(85)80396-6
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发表时间：
1985
影响因子：
3.3
通讯作者：
G. Lum
中科院分区：
文献类型：
--
作者：
B. Warady;S. Guggenheim;A. Sedman;G. Lum
Six children with biopsy-proved type 1 membranoproliferative glomerulonephritis (MPGN) improved clinically during a 2-year course of prednisone therapy. All children had nephrotic syndrome. Creatinine clearance was ≤80 ml/min/1.73 m2in four patients. Initial prednisone dosage ranged from 20 mg every other day to 2 mg/kg/day (maximum 60 mg), with subsequent modifications based on improvement. After completion of a 2-year course of steroid therapy, a repeat kidney biopsy was performed in each child; a decrease in glomerular disease activity was noted in five of them. After a mean follow-up of almost 5 years, all children have creatinine clearance >120 ml/min/1.73 m2, and only one remains nephrotic. Although the use of prednisone in children with MPGN remains controversial, we have observed a diminution in proteinuria and normalization of creatinine clearance with therapy initiated early in the disease course.
