Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger's disorders
Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger's disorders
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DOI：
10.1038/sj.npp.1300021
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发表时间：
2003-01-01
影响因子：
7.6
通讯作者：
Mosovich, S
中科院分区：
文献类型：
--
作者：
Hollander, E;Novotny, S;Mosovich, S
自闭症是一种神经发育障碍，其特征在于三个核心行为领域的功能障碍：重复行为，社交缺陷和语言异常。有证据表明，自闭症患者的肽系统，特别是催产素系统存在异常。此外，已知催产素和密切相关的肽加压素在社会和重复行为中发挥作用。本研究通过随机双盲催产素和安慰剂挑战，检查了催产素对15名患有自闭症或自闭症障碍的成年人重复行为的影响。主要的结果测量是一种工具，对六种重复行为进行评级：需要知道，重复，命令，需要告诉/问，自我伤害和触摸。与安慰剂输注相比，自闭症谱系障碍患者在催产素输注后的重复行为显着减少。自闭症谱系障碍中的重复行为可能与催产素系统的异常有关，并且可能通过合成催产素输注而部分改善。
Autism is a neurodevelopmental disorder characterized by dysfunction in three core behavioral domains: repetitive behaviors, social deficits, and language abnormalities. There is evidence that abnormalities exist in peptide systems, particularly the oxytocin system, in autism spectrum patients. Furthermore, oxytocin and the closely related peptide vasopressin are known to play a role in social and repetitive behaviors. This study examined the impact of oxytocin on repetitive behaviors in 15 adults with autism or Asperger's disorder via randomized double-blind oxytocin and placebo challenges. The primary outcome measure was an instrument rating six repetitive behaviors: need to know, repeating, ordering, need to tell/ask, self-injury, and touching. Patients with autism spectrum disorders showed a significant reduction in repetitive behaviors following oxytocin infusion in comparison to placebo infusion. Repetitive behavior in autism spectrum disorders may be related to abnormalities in the oxytocin system, and may be partially ameliorated by synthetic oxytocin infusion.