Changing the criteria for old/new recognition judgments can modulate activity in the anterior hippocampus
Changing the criteria for old/new recognition judgments can modulate activity in the anterior hippocampus
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DOI：
10.1002/hipo.20878
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发表时间：
2012-02-01
期刊：
影响因子：
3.5
通讯作者：
Mori, Etsuro
中科院分区：
文献类型：
--
作者：
Hashimoto, Ryusaku;Abe, Nobuhito;Mori, Etsuro
许多功能性磁共振成像（fMRI）研究表明，与熟悉的事物相比，当受试者遇到新事物时，内侧颞叶（MTL）被激活的程度更大。然而，MTL中的新颖性信号是否受到新旧识别判断标准的调节尚不清楚。在本研究中，我们使用功能磁共振成像来验证我们的假设，即当受试者遇到与以前遇到的相似的物品时，MTL中的新颖性信号将根据受试者关注物品的感知特征还是语义方面而有所不同。受试者研究了一系列照片，然后被要求在两种类型的任务中对(a)相同的项目（与编码过程中看到的项目相同），(b)相似的项目（与编码过程中看到的项目相似但不相同）和(c)新项目（未研究过的项目）做出识别判断：知觉和语义。被试判断这些项目是否与知觉任务中编码时看到的项目在知觉上相同，是否与语义任务中编码时看到的项目在语义上相同。左侧前海马体在两项任务中呈现相对于相同项目的新项目时被激活。此外，海马对相似项目的反应仅在知觉任务中增加，而在语义任务中没有增加。我们的研究结果表明，海马体中的新颖性信号可以通过新旧识别判断的标准来调节。(C) 2010 Wiley期刊公司
Numerous functional magnetic resonance imaging (fMRI) studies have reported that the medial temporal lobe (MTL) is activated to a greater extent when subjects encounter novel items as compared with familiar ones. However, it remains unclear whether the novelty signals in the MTL are modulated by the criteria for old/new recognition judgments. In this study, we used fMRI to test our hypothesis that when subjects encounter items similar to previously encountered ones, the novelty signals in the MTL will differ depending on whether the subjects focus on the perceptual features or the semantic aspects of the items. The subjects studied a series of photographs and were later asked to make a recognition judgment of (a) Same items (items identical to those seen during encoding), (b) Similar items (items similar to but not identical to those seen during encoding), and (c) New items (unstudied items) in two types of tasks: Perceptual and Semantic. The subjects judged whether the items were perceptually identical to those seen during encoding in the Perceptual task and whether the items were semantically identical to those seen during encoding in the Semantic task. The left anterior hippocampus was activated when subjects were presented with New items relative to Same items in both tasks. In addition, the hippocampal activity in response to the Similar items was increased only in the Perceptual, but not the Semantic task. Our results indicate that the novelty signals in the hippocampus can be modulated by criteria for old/new recognition judgments. (C) 2010 Wiley Periodicals, Inc.