Longitudinal Changes in Anterior Chamber Configuration in Eyes With Open-Angle Glaucoma and Associated Factors
Longitudinal Changes in Anterior Chamber Configuration in Eyes With Open-Angle Glaucoma and Associated Factors
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DOI：
10.1097/ijg.0b013e31821206b1
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发表时间：
2012-06-01
影响因子：
2
通讯作者：
Kashiwagi, Kenji
中科院分区：
文献类型：
--
作者：
Pan, Zhiying;Furuya, Toshie;Kashiwagi, Kenji
目的：目的：探讨原发性开角型青光眼患者前房深度（ACD）和前房角（ACA）的纵向变化及其相关因素。排除标准如下：激光或切口手术史，可能影响视野的其他眼部疾病，视力低于20/30，并接受匹鲁卡品滴眼液治疗。结果：157例青光眼患者和26例人工晶状体眼患者均接受了上述分析。青光眼患者的ACDG和ACA分别从7.2 ± 2.3度和34.2 ± 12.6度显著降低到6.5 ± 2.1度和28.1 ± 10.3度（P <0.0001），而白内障手术患者的ACDG和ACA没有显著变化。ACD的变化在周边区域比在中心区域更大。ACDG的减少与初始ACDG深和ACA宽显著相关。结论：ACDG和ACA随年龄增长而降低，初始ACDG和ACA与开角型青光眼的进展有关。
Purpose: To investigate longitudinal changes in anterior chamber depth (ACD) and anterior chamber angle (ACA) and the associated factors in patients with primary open-angle glaucoma using the scanning peripheral ACD analyzer.Methods: The scanning peripheral ACD analyzer evaluated ACD by numeric grade (ACDG 1 to 12) and ACA twice in 2003 and 2008. The exclusion criteria were as follows: history of laser or incisional surgery, other ocular diseases that may affect visual field, visual acuity less than 20/30, and treatment with pilocarpine ophthalmic solution. Patients with pseudophakic eye were used as control.Results: One hundred fifty-seven patients with glaucoma and 26 patients with pseudophakic eye were subjected to the analysis. ACDG and ACA of patients with glaucoma were significantly decreased from 7.2 +/- 2.3 to 6.5 +/- 2.1 (P < 0.001) and from 34.2 +/- 12.6 to 28.1 +/- 10.3 degrees (P < 0.0001), respectively, whereas patients with cataract surgery showed no significant changes in ACDG and ACA. The change in ACD was greater at the peripheral region than at the central region. The decrease in ACDG was significantly associated with deep initial ACDG and wide ACA. Patients having shallow ACDG and narrow ACA showed more rapid deterioration of visual field than those having deep ACDG and wide ACA.Conclusions: ACDG and ACA decreased with age, and initial ACDG and ACA were related to the progression of open-angle glaucoma.