Nonrandom chromosome changes in malignant melanoma.
Nonrandom chromosome changes in malignant melanoma.
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DOI：
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发表时间：
1983-10
期刊：
影响因子：
11.2
通讯作者：
R. Becher;Z. Gibas;C. Karakousis;A. Sandberg
中科院分区：
文献类型：
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作者：
R. Becher;Z. Gibas;C. Karakousis;A. Sandberg
对 4 例恶性黑色素瘤 (MM) 进行胶原酶解体和短期培养后的染色体畸变分析。在所有细胞培养物中，MM细胞呈现出典型的三角纺锤体形态。 1例染色体数目接近二倍体，3例接近三倍体。采用吉姆萨显带技术共鉴定出 27 条异常染色体。到目前为止，最常见的异常类型是易位，其次是缺失和等染色体。发现 1、6 和 7 号染色体最常涉及结构畸变。在所有 4 例病例中均发现了源自 1 号和 6 号染色体的标记，在 3 例中发现了 7 号染色体的异常。对于给定病例，每个标记染色体都是唯一的；没有发现两个或多个病例的共同标记。根据目前的结果以及文献中有关MM细胞染色体构成报道的分析，我们认为涉及6号和7号染色体的异常可能是MM的特征性特征。 1 号染色体畸变虽然在多发性骨髓瘤中很常见，但可能是人类肿瘤中一般细胞遗传学特征的一部分。
Chromosome aberrations were analyzed in 4 cases of malignant melanoma (MM) after disaggregation of the tumors with collagenase and short-term culture. In all cell cultures, the MM cells displayed a typical triangular spindle form. The chromosome number was near-diploid in one case and near-triploid in three cases. A total of 27 abnormal chromosomes were identified with the Giemsa banding technique. By far, the most common types of abnormalities were translocations, followed by deletions and isochromosomes. Chromosomes 1, 6, and 7 were found to be most frequently involved in structural aberrations. Markers originating from chromosomes 1 and 6 were found in all four cases, and abnormalities of chromosome 7 were found in three. Each marker chromosome was unique for a given case; no common markers for two or more cases were found. Based on the present results and an analysis of reports on the chromosomal constitution of MM cells in the literature, we suggest that abnormalities involving chromosomes 6 and 7 may be a characteristic feature of MM. Aberrations of chromosome 1, although common in MM, may be part of a general cytogenetic feature in human neoplasia.