Immunoreactivity of constitutive and inducible heat shock protein 70 in human fetal retina.
Immunoreactivity of constitutive and inducible heat shock protein 70 in human fetal retina.
复制标题
人胎儿视网膜中组成型和诱导型热休克蛋白 70 的免疫反应性。
DOI：
10.3341/kjo.2003.17.1.14
复制
发表时间：
2002
影响因子：
--
通讯作者：
C. Kim
中科院分区：
文献类型：
--
作者：
J. H. Kim;Y. Yu;Jin Hyoung Kim;Y. Kim;J. Heo;C. Kim
本研究的目的是测量诱导型热休克蛋白70（Hsp 70），组成型热休克蛋白70（Hsc 70）在人胚胎视网膜的外核层和光感受器的表达水平。胎儿眼球选自12和17 - 40周龄胎儿的尸检标本，无先天性异常史。视网膜已从神经母细胞分化为成熟的感觉视网膜，从胎龄（GA）为12至36周。Hsp 70和Hsc 70主要表达于细胞核层。Hsc 70在所有GA中表达，Hsp 70在GA 20 - 33周表达。这一时期与感觉视网膜的成熟一致。热休克蛋白的表达可能受胎儿发育的调控，在眼的发育过程中起重要作用。
The purpose of this study was to measure the level of expression of the inducible heat shock protein70 (Hsp70), the constitutive heat shock protein70 (Hsc70) in the outer nuclear layer and the photoreceptors in the human fetal retina. Fetal eyeballs were selected from fetal autopsy specimens of 12 and 17 to 40 week old fetuses, with no history of congenital anomalies. The retinas had differentiated from neuroblastic cells, into matured sensory retinas, from a gestational age (GA) from 12 to 36 weeks. The Hsp70 and Hsc70 were prominently expressed in the nuclear layers. The Hsc70 was expressed at all GAs and the Hsp70 was expressed from 20 to 33 weeks GA. This period is in accordance with the maturation of the sensory retina. The expression of heat shock protein may be regulated by the development of the fetus, and play an important role in the ocular development.