Nomogram for stratifying patients with lifelong premature ejaculation before using the PHQ-9: An observational study
Nomogram for stratifying patients with lifelong premature ejaculation before using the PHQ-9: An observational study
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DOI：
10.1111/eci.13809
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发表时间：
2022-05-22
影响因子：
5.5
通讯作者：
Yuan，Jianlin
中科院分区：
文献类型：
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作者：
Hou，Guangdong;Gao，Ming;Yuan，Jianlin
目的PHQ-9评分≥ 15，表示为PHQ-9+，表明患有重度抑郁症（MDD）。在使用PHQ-9时，一些终身早泄（LPE）患者的心理负担加重，这可能导致LPE的发展。目的构建预测LPE患者PHQ-9+个体风险的列线图，并识别低风险者，避免PHQ-9。方法分析西京医院和西北妇女儿童医院802例LPE患者的资料，构建列线图。使用LASSO和多变量logistic回归来确定PHQ-9+的独立预测因子，用于绘制列线图。在推导队列和独立验证队列中评估列线图的鉴别、校准和临床有用性，该队列由来自大兴医院和西京医院的505例前瞻性入组患者组成。结果PE持续时间、IELT、PE加重史、IIEF-5评分、尿频和躯体疼痛评分被确定为独立预测因子。诺模图在推导和验证队列中显示出良好的校准、区分和临床实用性，预测准确度分别为0.781和0.763。根据该列线图，将患者分为不推荐、推荐和强烈推荐的PHQ-9填充组，PHQ-9+率分别为3.5%、9.3%和30.7%.ConclusionA nomogram to discuss LPE patients with low risk of PHQ-9+was established.该工具可以增加MDD筛查的阳性率，并可能改善低风险组患者的治疗结局。
ObjectiveA PHQ‐9 score ≥ 15, represented as PHQ‐9+, indicates major depressive disorder (MDD). On using PHQ‐9, the psychological burden of several patients with lifelong premature ejaculation (LPE) gets aggravated, which may lead to LPE development. We aim to construct a nomogram for predicting the individual risk of PHQ‐9+in patients with LPE and discerning those with low risks, who should avoid the PHQ‐9.MethodsThe nomogram was constructed by analysing data of 802 patients from Xijing Hospital and Northwest Women's & Children's Hospital. The LASSO and multivariable logistic regressions were used to identify independent predictors of PHQ‐9+, used for developing the nomogram. The discrimination, calibration and clinical usefulness of the nomogram were assessed in the derivation cohort and an independent validation cohort, which was composed of 505 prospectively enrolled patients from Daxing Hospital and Xijing Hospital.ResultsThe duration of PE, IELT, a history of PE exacerbation, IIEF‐5 score, urinary frequency and physical pain score were identified as independent predictors. The nomogram showed excellent calibration, discrimination and clinical usefulness in the derivation and validation cohorts, with a predictive accuracy of 0.781 and 0.763, respectively. Based on this nomogram, patients were divided into not recommended, recommended and strongly recommended PHQ‐9 filling groups, with PHQ‐9+rates of 3.5%, 9.3% and 30.7%, respectively.ConclusionA nomogram to discern LPE patients with low risks of PHQ‐9+was established. This tool can increase the positivity of MDD screening and may improve the therapeutic outcomes of those in the low‐risk group.