Influence of CYP11B2 Gene Polymorphism on the Prevalence of Hypertension and the Blood Pressure in Japanese Men: Interaction with Dietary Salt Intake
Influence of CYP11B2 Gene Polymorphism on the Prevalence of Hypertension and the Blood Pressure in Japanese Men: Interaction with Dietary Salt Intake
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DOI：
10.1159/000150006
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发表时间：
2008-08
影响因子：
2.6
通讯作者：
Yixuan Song;K. Miyaki;J. Araki;Ling Zhang;Yoshimitsu Takahashi;T. Nakayama;M. Muramatsu
中科院分区：
文献类型：
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作者：
Yixuan Song;K. Miyaki;J. Araki;Ling Zhang;Yoshimitsu Takahashi;T. Nakayama;M. Muramatsu
目的：CYP11B2基因编码醛固酮生成的关键酶。我们的目的是研究-344T /C多态性与日本男性高血压的关系。研究还考虑了基因型与盐摄入量之间的相互作用。方法：以310名日本男性员工为研究对象。每日盐摄入量是根据食物频率问卷计算的。采用熔融曲线分析确定CYP11B2基因型。结果：CT + TT基因型与高血压高患病率有显著相关性（优势比：3.03;p = 0.014）。相关性以隐性方式呈现，在高盐摄入组最强（优势比：9.44;p = 0.049）。只有在高摄入组，CT + TT组的收缩压（SBP）明显高于CC组（p = 0.038）。CT + TT组的收缩压与盐摄入量呈正相关（线性趋势p = 0.021），而CC组的收缩压与盐摄入量呈正相关（相互作用p = 0.011）。结论：CYP11B2基因-344C /T多态性影响日本男性高血压的风险，高盐摄入水平强化了这种关联。这种基因-饮食相互作用值得进一步研究，以阐明盐限制作为不同基因型抗高血压治疗的疗效。
Aims: CYP11B2 gene encodes a key enzyme for the production of aldosterone. Our aim is to investigate the association of –344T/C polymorphism with hypertension in Japanese men. The interaction between genotypes and dietary salt intake was also considered. Methods: Three hundred and ten Japanese male workers participated in this study. Daily salt intake was calculated from a food frequency questionnaire. Melting curve analysis was used to determine CYP11B2 genotypes. Results:There was a significant association between the CT + TT genotype and higher prevalence of hypertension (odds ratio: 3.03; p = 0.014). The association presented in a recessive manner and was strongest in the high-salt intake group (odds ratio: 9.44; p = 0.049). Only in the high-intake group, systolic blood pressure (SBP) was significantly higher in the CT + TT group than in the CC group (p = 0.038). The SBP had a positive correlation with salt intake in the CT + TT group (p for linear trend = 0.021), but not in the CC group (p for interaction = 0.011). Conclusions: CYP11B2 gene –344C/T polymorphism affects the risk of hypertension in Japanese men and high-salt intake levels strengthen this association. This gene-diet interaction warrants further study to elucidate the efficacy of salt restriction as an antihypertensive therapy in different genotypes.