Peripheral application of cyclo-somatostatin, a somatostatin antagonist, increases the mechanosensitivity of rat knee joint afferents
Peripheral application of cyclo-somatostatin, a somatostatin antagonist, increases the mechanosensitivity of rat knee joint afferents
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DOI：
10.1016/s0304-3940(98)00912-4
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发表时间：
1999-01
影响因子：
2.5
通讯作者：
B. Heppelmann;M. Pawlak
中科院分区：
文献类型：
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作者：
B. Heppelmann;M. Pawlak
最近，它已被证明，神经肽可能参与调节的机械敏感性的精细传入神经纤维。生长抑素似乎对正常组织中感觉末梢的敏感性提供了紧张性抑制。在本研究中，环生长抑素，生长抑素拮抗剂，被用来测试这一假设。在一个正常的关节，50%（8/16）的初级传入检查后，环生长抑素的应用程序显着增加其对有害的关节运动的反应。然而，在急性发炎的关节中，只有9%（1/11）的神经纤维显著增加了对有害运动的反应。这些数据进一步支持了这样的假设，即正常关节中关节传入的机械敏感性也受到促炎肽和抗炎肽（如生长抑素）的平衡的调节。在发炎的关节中，促炎肽占主导地位，并且与其他介质一起，它们可能参与外周神经纤维的敏化。
Recently it has been shown that neuropeptides may be involved in the regulation of the mechanosensitivity of fine afferent nerve fibres. Somatostatin seems to provide a tonic inhibition of the sensitivity of sensory endings in normal tissue. In the present study cyclo-somatostatin, a somatostatin antagonist, was used to test this hypothesis. In a normal joint, 50% (8/16) of the examined primary afferents significantly increased their responses to noxious joint movements after the cyclo-somatostatin application. In an acutely inflamed joint, however, only 9% (1/11) of the nerve fibres significantly increased the response to noxious movements. These data further support the hypothesis that the mechanosensitivity of articular afferents in a normal joint is also regulated by a balance of pro-inflammatory peptides and anti-inflammatory peptides such as somatostatin. In an inflamed joint, pro-inflammatory peptides predominate and together with other mediators, they may be involved in the sensitization of the peripheral nerve fibres.