Increasing incidences of inflammatory bowel disease and decreasing surgery rates in copenhagen city and county, 2003-2005: A population-based study from the Danish crohn colitis database
Increasing incidences of inflammatory bowel disease and decreasing surgery rates in copenhagen city and county, 2003-2005: A population-based study from the Danish crohn colitis database
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DOI：
10.1111/j.1572-0241.2006.00552.x
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发表时间：
2006-06-01
影响因子：
9.8
通讯作者：
Munkholm, Pia
中科院分区：
文献类型：
--
作者：
Vind, Ida;Riis, Lene;Munkholm, Pia
目的：炎症性肠道疾病（IBD）、克罗恩病（CD）、溃疡性结肠炎（UC）和不确定性结肠炎（IC）的发病率不断增加。由于丹麦提供了良好的条件，流行病学研究，我们的目的是描述当代IBD发病率和患者的特点，在哥本哈根县和City.METHODS：所有患者诊断IBD在2003-2005年进行了前瞻性随访。人口统计学和临床特征，如疾病程度，肠外表现，吸烟习惯，药物治疗，手术干预，癌症和死亡，registered.RESULTS：562例患者被诊断为IBD，导致平均年发病率为8.6/10（5）CD，13.4/10（5）UC和1.1/10（5）IC。CD患者从发病到诊断的时间为8.3个月，UC患者为4.5个月。IBD、吸烟和肠外表现的家族史在CD患者中比UC患者更常见。只有0.6%的UC患者有原发性硬化性胆管炎。在CD中，诊断时年龄较大与单纯结肠疾病相关，而儿童则更常发生近端和广泛受累。12%的CD患者和6%的UC患者在诊断的一年内接受手术，显着低于早期reported.CONCLUSIONS：IBD在哥本哈根的发病率显着增加，在过去的几十年。从症状发作到确诊的时间明显缩短，CD的程度与确诊时的年龄相关，UC的手术风险较低。
OBJECTIVES: A continuous increase in the incidence of inflammatory bowel disease (IBD), Crohn's disease (CD), ulcerative colitis (UC), and indeterminate colitis (IC) has been suggested. Since Denmark provides excellent conditions for epidemiological research, we aimed to describe contemporary IBD incidence rates and patient characteristics in Copenhagen County and City.METHODS: All patients diagnosed with IBD during 2003-2005 were followed prospectively. Demographic and clinical characteristics, such as disease extent, extraintestinal manifestations, smoking habits, medical treatment, surgical interventions, cancer, and death, were registered.RESULTS: Five-hundred sixty-two patients were diagnosed with IBD, resulting in mean annual incidences of 8.6/10(5) for CD, 13.4/10(5) for UC, and 1.1/10(5) for IC. Time from onset to diagnosis was 8.3 months in CD and 4.5 months in UC patients. A family history of IBD, smoking, and extraintestinal manifestations was significantly more common in CD than in UC patients. Only 0.6% of UC patients had primary sclerosing cholangitis. In CD, old age at diagnosis was related to pure colonic disease, whereas children significantly more often had proximal and extensive involvement. Twelve percent of CD patients and 6% of UC patients underwent surgery during the year of diagnosis, significantly less than earlier reported.CONCLUSIONS: The incidence of IBD in Copenhagen increased noticeably during the last decades. Time from onset of symptoms until diagnosis decreased markedly, extent of CD was related to age at diagnosis, and the risk of surgery was low in UC.