Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges.
Human interictal epileptiform discharges are bidirectional traveling waves echoing ictal discharges.
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人类发作期癫痫样放电是与发作期放电相呼应的双向行波。
DOI：
10.7554/elife.73541
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发表时间：
2022-01-20
期刊：
影响因子：
7.7
通讯作者：
Rolston JD
中科院分区：
文献类型：
--
作者：
Smith EH;Liou JY;Merricks EM;Davis T;Thomson K;Greger B;House P;Emerson RG;Goodman R;McKhann GM;Sheth S;Schevon C;Rolston JD
发作间期癫痫样放电(IEDS)，也称为发作间期棘波，是癫痫患者发作之间观察到的大的间歇性电生理事件。尽管IED比癫痫发生得更频繁，但对IED的研究较少，而且它们与癫痫的关系尚不清楚。为了更好地了解这种关系，我们检查了植入人类癫痫患者体内的微电极阵列的多天记录，使我们能够准确观察IED的时空传播、自发性癫痫发作以及它们之间的关系。这些记录显示，大多数IED是行波，在癫痫发作期间穿过与发作性放电相同的路径，并且相对于癫痫的传播具有固定的方向。此外，大多数IED，如发作性放电，是双向的，一个占主导地位，第二个，较少出现对足方向。这些结果揭示了IED和发作放电之间的基本时空相似性。这些结果还表明，大多数IED出现在癫痫发作部位以外的脑组织中，并向那里传播，表明IED的传播为定位癫痫灶提供了有用的信息。
Interictal epileptiform discharges (IEDs), also known as interictal spikes, are large intermittent electrophysiological events observed between seizures in patients with epilepsy. Although they occur far more often than seizures, IEDs are less studied, and their relationship to seizures remains unclear. To better understand this relationship, we examined multi-day recordings of microelectrode arrays implanted in human epilepsy patients, allowing us to precisely observe the spatiotemporal propagation of IEDs, spontaneous seizures, and how they relate. These recordings showed that the majority of IEDs are traveling waves, traversing the same path as ictal discharges during seizures, and with a fixed direction relative to seizure propagation. Moreover, the majority of IEDs, like ictal discharges, were bidirectional, with one predominant and a second, less frequent antipodal direction. These results reveal a fundamental spatiotemporal similarity between IEDs and ictal discharges. These results also imply that most IEDs arise in brain tissue outside the site of seizure onset and propagate toward it, indicating that the propagation of IEDs provides useful information for localizing the seizure focus.