Epidermolysis bullosa simplex (Koebner) is a keratin disorder. Ultrastructural and immunohistochemical study.
Epidermolysis bullosa simplex (Koebner) is a keratin disorder. Ultrastructural and immunohistochemical study.
复制标题
单纯性大疱性表皮松解症（Koebner）是一种角蛋白疾病。
作者：
M. Ito;C. Okuda;N. Shimizu;T. Tazawa;Y. Sato
皮肤活检标本取自一名患有单纯性大疱性表皮松解症 (Koebner) 的 1 个月大女性。在组织学上，观察到表皮内分离并认为是由表皮基底细胞的细胞溶解形成的。超微结构观察，基底细胞缺乏细胞质张力丝，细胞溶解的最初变化似乎是细胞质的裂解。免疫组织化学显示，基底细胞角蛋白在基底上细胞层中表达，但在基底细胞层中不表达，并且在基底细胞层中未检测到全上皮角蛋白。这些发现表明，表皮细胞的角蛋白产生可能被延迟，导致基底细胞抵抗皮肤轻微创伤的能力减弱。
A skin biopsy specimen was obtained from a 1-month-old female with epidermolysis bullosa simplex (Koebner). Histologically, an intraepidermal separation was seen and considered to be formed by cytolysis of the epidermal basal cells. Ultrastructurally, the basal cells were lacking in cytoplasmic tonofilaments, and the initial change of the cytolysis seemed to be cleavages of the cytoplasm. Immunohistochemically, a basal cell keratin was expressed in a suprabasal cell layer but not in the basal cell layer, and a panepithelial keratin was not detected in the basal cell layer. These findings suggest that keratin production of the epidermal cells may be delayed, resulting in a weakness of the basal cells against minor trauma to the skin.
广泛性显性单纯性大疱性表皮松解症：作为表型标记的培养成纤维细胞中明胶分解蛋白酶的活性降低。
DOI：
10.1111/1523-1747.ep12523269
发表时间：
1983
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
Sanchez,G;Seltzer,JL;Eisen,AZ;Stapler,P;Bauer,EA
通讯作者：
Bauer,EA