IgG rheumatoid factor. Relationship to seropositive rheumatoid arthritis and absence in seronegative disorders.
IgG rheumatoid factor. Relationship to seropositive rheumatoid arthritis and absence in seronegative disorders.
复制标题
IgG 类风湿因子。
作者：
R. Pope;S. McDuffy
IgG类风湿因子在大多数血清阳性的类风湿关节炎患者的血清中检测到。四分之一的血清阴性炎性关节病患者的IgG类风湿因子值提示。这些测定值始终较低，并与IgG浓度升高相关，表明IgG的非特异性粘附，而不是真正的抗原-抗体反应。支持这一结论，非类风湿因子IgG能够浓度依赖性非特异性吸附的固相。IgG，但不是IgM，类风湿因子与疾病活动性血清阳性类风湿关节炎患者，表明IgG类风湿因子可能是重要的发病机制。
IgG rheumatoid factor was detected in the sera of the majority of patients with seropositive rheumatoid arthritis. Values suggestive of IgG rheumatoid factor were noted in one-quarter of patients with seronegative inflammatory arthropathies. These determinations were always low and correlated with elevated IgG concentrations, suggesting nonspecific adherence of IgG rather than a true antigen-antibody reaction. In support of this conclusion, nonrheumatoid factor IgG was capable of concentration-dependent nonspecific adsorption to the solid phase. IgG, but not IgM, rheumatoid factor corresponded with disease activity in patients with seropositive rheumatoid arthritis, suggesting that IgG rheumatoid factor may be important in the pathogenesis.