Endometriosis research using capture microdissection techniques: Progress and future applications.
Endometriosis research using capture microdissection techniques: Progress and future applications.
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DOI：
10.3892/br.2016.758
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发表时间：
2016-11
影响因子：
2.3
通讯作者：
Luyang Zhao;C. Gu;Ke Huang;W. Han;Meng Fu;Y. Meng
中科院分区：
文献类型：
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作者：
Luyang Zhao;C. Gu;Ke Huang;W. Han;Meng Fu;Y. Meng
子宫内膜异位症是一种常见病，发病率高，但其病因和病理生理尚不完全清楚。先前的证据表明，这种疾病可能部分或完全源于躯体。然而，传统的子宫内膜样本可能不适合研究，因为子宫内膜异位症病变中的靶细胞（包括上皮细胞和基质细胞）太稀疏而无法分析。最近，在子宫内膜异位症的研究中，捕获显微解剖技术已经被用来克服这些限制和消除组织异质性。因此，本文综述了通过捕获显微解剖分离的子宫内膜异位症组织中上皮细胞和基质细胞的变化，概述了近年来的研究进展，并为进一步研究子宫内膜异位症的发病机制提供了方向。
Endometriosis is a common gynecological disease with high prevalence, while its etiology and pathophysiology have remained to be fully elucidated. Previous evidence suggested that this disorder may be in part or completely of somatic origin. However, traditional endometrial samples may not be ideal for investigation, as target cells, including epithelial and stromal cells, in endometriotic lesions are too sparse to be analyzed. Recently, capture microdissection techniques have been used to overcome these limitations and eliminate tissue heterogeneity in endometriosis research. Therefore, the present review summarized the alterations in epithelial and stromal cells in endometriosis tissues isolated through capture microdissection, outlined recent progress and provided directions for future investigation of the pathogenesis of endometriosis.