Fibroblast precursors in normal and irradiated mouse hematopoietic organs.
Fibroblast precursors in normal and irradiated mouse hematopoietic organs.
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DOI：
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发表时间：
1976-09
影响因子：
2.6
通讯作者：
A. Friedenstein;J. F. Gorskaja;N. Kulagina
中科院分区：
文献类型：
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作者：
A. Friedenstein;J. F. Gorskaja;N. Kulagina
使用体外集落测定，在成年小鼠的骨髓、脾脏和胸腺中检测到克隆形成的成纤维细胞前体细胞（CFU-F）。体外照射小鼠骨髓CFU-F的存活曲线D0为220 r。 150μl全身照射后骨髓CFU-F的再生特征是明显的继发性损失和照射后滞后和下降，持续6天，然后在第25天左右恢复到正常值。 CFU-F 的辐射后恢复模式与 CFU-s 类似。此外，在照射后的前 6 小时内，CFU-F 的数量增加了大约两倍。
Using the in vitro colony assay, clonogenic fibroblast precursor cells (CFU-F) were detected in the bone marrow, spleen and thymus from adult mice. The survival curve for CFU-F of mouse bone marrow irradiated in vitro has a D0 of 220 r. Regeneration of bone marrow CFU-F after whole-body irradiation with 150 r is characterized by a marked secondary loss and post-irradiation lag and dip, lasting 6 days, followed by return to normal values by about the 25th day. This pattern of post-radiation recovery of CFU-F is similar to that of the CFU-s. In addition, during the first 6 hours following irradiation the number of CFU-F increased approximately twofold.