The mechanism of action of T7 DNA polymerase
The mechanism of action of T7 DNA polymerase
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DOI：
10.1016/s0959-440x(98)80089-4
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发表时间：
1998-12-01
影响因子：
6.8
通讯作者：
Ellenberger, T
中科院分区：
文献类型：
--
作者：
Doublié, S;Ellenberger, T
The recent crystal structure determination of T7 DNA polymerase complexed to a deoxynucleoside triphosphate and primer-template DNA has provided the first glimpse of a replicative DNA polymerase in a catalytic complex. The structure complements many functional and structural studies of this and other DNA polymerases, allowing a detailed evaluation of proposals for the mechanism of nucleotidyl transfer and the exploration of the basis for the high fidelity of template-directed DNA synthesis.
