Nitric Oxide Donors for the Treatment of Osteoporosis
Nitric Oxide Donors for the Treatment of Osteoporosis
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DOI：
10.1007/s11914-011-0087-7
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发表时间：
2012-03-01
影响因子：
4.3
通讯作者：
Hamilton, Celeste J.
中科院分区：
文献类型：
--
作者：
Jamal, Sophie A.;Hamilton, Celeste J.
随着人口老龄化，骨质疏松性骨折的数量在全球范围内不断增加。需要一种廉价且广泛可用的治疗方法来缓解骨折的增加。目前的治疗方法减少了骨小梁部位（脊柱）的骨折，但对皮质部位（髋关节、腿部、前臂和上臂）的效果有限，皮质部位是骨质疏松性骨折最常见的部位。治疗也受到费用、副作用和缺乏可用性的限制。一氧化氮是一种可能影响骨皮质的新型药物，价格低廉，可广泛使用，副作用有限。在这篇综述中，我们评估了体外和体内数据，这些数据支持一氧化氮在骨细胞功能中很重要的概念，回顾了观察性和病例对照研究，报告了使用有机硝酸盐作为一氧化氮供体的受试者，并回顾了硝酸盐对骨密度测量和骨折风险的影响。
The number of osteoporotic fractures is increasing worldwide as populations age. An inexpensive and widely available treatment is necessary to alleviate this increase in fractures. Current treatments decrease fractures at trabecular bone sites (spine) but have limited effects at cortical sites (hip, legs, forearm, and upper arm)-the most common sites of osteoporotic fracture. Treatments are also limited by costs, side effects, and lack of availability. Nitric oxide is a novel agent that has the potential to influence cortical bone, is inexpensive, is widely available, and has limited side effects. In this review we evaluate the in vitro and in vivo data which support the concept that nitric oxide is important in bone cell function, review the observational and case-control studies reporting on subjects taking organic nitrates that act as nitric oxide donors, and review the effects of nitrates on bone mineral density measurements and fracture risk.