Autologous Adipose Tissue Graft to Treat Hypertensive Leg Ulcer: A Pilot Study
Autologous Adipose Tissue Graft to Treat Hypertensive Leg Ulcer: A Pilot Study
复制标题
DOI：
10.1159/000478009
复制
发表时间：
2017-01-01
期刊：
影响因子：
3.4
通讯作者：
Dompmartin, A.
中科院分区：
文献类型：
--
作者：
Chopinaud, M.;Labbe, D.;Dompmartin, A.
背景资料：脂肪组织是间充质干细胞的丰富来源，称为脂肪源性干细胞，其具有抗炎和营养作用，以增强整体组织修复。目的：探讨自体脂肪组织移植治疗下肢高血压性溃疡的疗效。方法：在法国1个皮肤科进行前瞻性试点研究。2013年4月至2015年6月入组了10例高血压腿部溃疡患者。主要终点是每次随访时的伤口闭合率。次要终点为伤口特征、疼痛评估和不良事件。结果：1例患者（唯一的吸烟者）在第5个月（M5）失访。对于9名非吸烟者，伤口表面持续显著减少：M3时的中位伤口闭合率为73.2%，M6时为93.1%，p < 0.001。M3时，10例患者的中位伤口闭合率为63.2%，p < 0.001。纤维蛋白和坏死组织减少，肉芽组织明显增多。疼痛迅速显著减轻。未观察到复发或不良事件。结论：我们的数据表明，自体脂肪组织移植可缓解疼痛，促进伤口愈合，皮肤质量良好。需要进行大型前瞻性随机对照研究来证实这些结果。(C)2017 S. Karger AG，巴塞尔
Background: Adipose tissue is an abundant source of mesenchymal stem cells, called adipose-derived stem cells, which have anti-inflammatory and trophic effects to enhance overall tissue repair. Objective: To determine the healing effects of autologous adipose tissue graft on hypertensive leg ulcers. Methods: Prospective pilot study in 1 French dermatology department. Ten patients with a hypertensive leg ulcer were enrolled from April 2013 to June 2015. The primary end point was the wound closure rate at each follow-up visit. The secondary end points were wound characteristics, pain assessment and adverse events. Results: One patient, the only smoker, was lost to follow-up at month 5 (M5). For the 9 non-smokers, wound surfaces constantly and significantly decreased: the median wound closure rate was 73.2% at M3 and 93.1% at M6, p < 0.001. The median wound closure rate of the 10 patients was 63.2% at M3, p < 0.001. Percentages of fibrin and necrosis decreased, granulation tissue increased significantly. Pain rapidly and significantly decreased. No recurrence or adverse event was observed. Conclusion: Our data suggest that autologous adipose tissue grafting induces pain relief and promotes wound healing with a good skin quality. Large prospective controlled randomized studies are required to confirm these results. (C) 2017 S. Karger AG, Basel