Association between α-tocopherol, γ-tocopherol, selenium, and subsequent prostate cancer
Association between α-tocopherol, γ-tocopherol, selenium, and subsequent prostate cancer
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DOI：
10.1093/jnci/92.24.2018
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发表时间：
2000-12-20
期刊：
影响因子：
--
通讯作者：
Comstock, GW
中科院分区：
文献类型：
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作者：
Helzlsouer, KJ;Huang, HY;Comstock, GW
背景：硒和α -生育酚，补充剂中维生素E的主要形式，似乎对前列腺癌有保护作用。然而，很少有人注意到γ -生育酚的可能作用。γ -生育酚是美国人饮食中维生素E的主要成分，也是人类血清中第二常见的生育酚。我们进行了一项巢式病例对照研究，以检验α -生育酚、γ -生育酚和硒与前列腺癌发病的关系。方法：1989年，马里兰州华盛顿县共有10456名男性居民向一家血库献血。145名患前列腺癌的男性中有117名和233名对照者有脚趾甲和血浆样本，用于检测硒、α -生育酚和γ -生育酚。微量营养素浓度与前列腺癌发生之间的关系通过条件logistic回归分析进行评估。所有统计检验均为双侧检验。结果：随着α -生育酚浓度的增加，前列腺癌的风险下降，但不是线性的(优势比（最高与最低的五分之一）= 0.65；95%置信区间= 0.32-1.32；P-trend = .28)。对于γ -生育酚，分布中最高的五分之一的男性患前列腺癌的风险比最低的五分之一的男性低五倍（p趋势= 0.002）。硒与前列腺癌风险之间的关系是保护性的，分布中排名前五分之四的个体患前列腺癌的风险比排名后五分之一的个体低（p趋势= 0.27）。只有当γ -生育酚浓度高时，才观察到高水平硒和α -生育酚具有统计学意义的保护作用。结论：考虑到α -生育酚、γ -生育酚和硒之间的相互作用，在即将进行的前列腺癌预防试验中应考虑联合使用α -和γ -生育酚补充剂。
Background: Selenium and alpha -tocopherol, the major form of vitamin E in supplements, appear to have a protective effect against prostate cancer. However, little attention has been paid to the possible role of gamma -tocopherol, a major component of vitamin E in the U.S. diet and the second most common tocopherol in human serum. A nested case-control study was conducted to examine the associations of alpha -tocopherol, gamma -tocopherol, and selenium with incident prostate cancer. Methods: In 1989, a total of 10 456 male residents of Washington County, MD, donated blood for a specimen bank. A total of 117 of 145 men who developed prostate cancer and 233 matched control subjects had toenail and plasma samples available for assays of selenium, alpha -tocopherol, and gamma -tocopherol. The association between the micronutrient concentrations and the development of prostate cancer was assessed by conditional logistic regression analysis. All statistical tests were two-sided. Results: The risk of prostate cancer declined, but not linearly, with increasing concentrations of alpha -tocopherol (odds ratio(highest versus lowest fifth) = 0.65; 95% confidence interval = 0.32-1.32; P-trend = .28). For gamma -tocopherol, men in the highest fifth of the distribution had a fivefold reduction in the risk of developing prostate cancer than men in the lowest fifth (P-trend = .002). The association between selenium and prostate cancer risk was in the protective direction with individuals in the top four fifths of the distribution having a reduced risk of prostate cancer compared with individuals in the bottom fifth (P-trend = .27). Statistically significant protective associations for high levels of selenium and alpha -tocopherol were observed only when gamma -tocopherol concentrations were high. Conclusions: The use of combined alpha- and gamma- tocopherol supplements should be considered in upcoming prostate cancer prevention trials, given the observed interaction between alpha -tocopherol, gamma -tocopherol, and selenium.