Informatic parcellation of the network involved in the computation of subjective value
Informatic parcellation of the network involved in the computation of subjective value
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DOI：
10.1093/scan/nst106
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发表时间：
2014-09-01
影响因子：
4.2
通讯作者：
Rangel, Antonio
中科院分区：
文献类型：
--
作者：
Clithero, John A.;Rangel, Antonio
理解大脑如何计算价值是神经科学的一个基本问题。虽然个别研究推动了这一进展，但荟萃分析提供了一个机会来检验需要大量数据收集的假设。我们对价值计算的大量功能性磁共振成像研究进行了荟萃分析，以解决几个关键问题。首先，当需要计算刺激值时，与刺激值可靠相关的全部大脑区域是什么？第二，这组区域是否被组织成可分离的功能网络？第三，在决策和结果的刺激值的计算中是否有一个不同的区域网络？最后，对于不同的奖励模式，不同的大脑区域是否参与了刺激值的计算？我们的研究结果表明，腹内侧前额叶皮层（VMPFC）、腹侧纹状体和后扣带皮层（PCC）在跨任务、奖励方式和决策过程阶段的价值计算中处于中心地位。我们还发现了VMPFC内共同激活的不同子网络的证据，一个涉及VMPFC中央和背侧PCC，另一个涉及更多的VMPFC前部，左角回和腹侧PCC。最后，我们确定了对应于具体到抽象奖励的价值表征的后向前梯度。
Understanding how the brain computes value is a basic question in neuroscience. Although individual studies have driven this progress, meta-analyses provide an opportunity to test hypotheses that require large collections of data. We carry out a meta-analysis of a large set of functional magnetic resonance imaging studies of value computation to address several key questions. First, what is the full set of brain areas that reliably correlate with stimulus values when they need to be computed? Second, is this set of areas organized into dissociable functional networks? Third, is a distinct network of regions involved in the computation of stimulus values at decision and outcome? Finally, are different brain areas involved in the computation of stimulus values for different reward modalities? Our results demonstrate the centrality of ventromedial prefrontal cortex (VMPFC), ventral striatum and posterior cingulate cortex (PCC) in the computation of value across tasks, reward modalities and stages of the decision-making process. We also find evidence of distinct subnetworks of co-activation within VMPFC, one involving central VMPFC and dorsal PCC and another involving more anterior VMPFC, left angular gyrus and ventral PCC. Finally, we identify a posterior-to-anterior gradient of value representations corresponding to concrete-to-abstract rewards.