A 5-7 year in vivo study of high-strength hydroxyapatite/poly(L-lactide) composite rods for the internal fixation of bone fractures
A 5-7 year in vivo study of high-strength hydroxyapatite/poly(L-lactide) composite rods for the internal fixation of bone fractures
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DOI：
10.1016/j.biomaterials.2005.09.003
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发表时间：
2006-03-01
期刊：
影响因子：
14
通讯作者：
Nakamura, T
中科院分区：
文献类型：
--
作者：
Hasegawa, S;Ishii, S;Nakamura, T
以未煅烧的羟基磷灰石（u-HA）和煅烧的羟基磷灰石（c-HA）为增强填料，研究了羟基磷灰石/聚L-乳酸（PLLA）复合骨植入棒的生物相容性和生物降解性。将u-HA/PLLA和c-HA/PLLA复合棒植入25只家兔股骨远端。其中4只存活5年以上，1只存活7年4个月。自然死亡后取标本，光镜和扫描电镜观察。对于u-HA/PLLA，棒的收缩在4年后进一步发展，并且一些棒几乎完全被吸收。我们无法在超过6年的某些部分中找到棒的痕迹。重塑骨包围残留材料，并发现骨小梁直接粘合到棒的中心。对于u-HA/PLLA 30%，结果与u-HA/PLLA 40%相似，7年后横截面积减少了4.0%。大部分PLLA已从棒中释放。4年后未见明显溶骨性和骨关节炎性改变。(c)2005爱思唯尔有限公司保留所有权利。
The biocompatibility and biodegradation of hydroxyapatite (HA)/poly(L-lactide) (PLLA) composite bone implant rods were studied using two types of HA particles as reinforcing fillers, uncalcined-HA (u-HA) or calcined-HA (c-HA). Composite rods of u-HA/PLLA and c-HA/PLLA were implanted into the distal femurs of 25 rabbits. Four of these rabbits lived for more than 5 years after implantation, with one living for 7 years 4 months. Samples were retrieved after the rabbits died naturally and specimens were examined by light microscopy and scanning electron microscopy (SEM). For u-HA/PLLA, the shrinkage of the rods progressed further after 4 years, and some were almost completely resorbed. We could not find traces of the rod in some sections from more than 6 years. Remodeled bone encircled the residual material, and trabecular bone bonded directly to the rod was found toward the center. For u-HA/PLLA 30%, results were similar to u-HA/PLLA 40%, and the cross-sectional area had decreased by 4.0% at over 7 years. Most of the PLLA had been released from the rods. Neither obvious osteolytic nor osteoarthritic changes were found after 4 years. (c) 2005 Elsevier Ltd. All rights reserved.