Downregulation of snoRNA SNORA52 and Its Clinical Significance in Hepatocellular Carcinoma.
Downregulation of snoRNA SNORA52 and Its Clinical Significance in Hepatocellular Carcinoma.
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DOI：
10.1155/2021/7020637
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发表时间：
2021
影响因子：
--
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Ding Y;Sun Z;Zhang S;Li Y;Han X;Xu Q;Zhou L;Xu H;Bai Y;Xu C;Ding H;Ge Y;Wang W
肝细胞癌 (HCC) 是世界上最常见和最具侵袭性的肿瘤之一，而目前检测 HCC 的测试的准确性很差。迫切需要一种新的 HCC 诊断和预后生物标志物。压倒性的证据证明了小核仁 RNA (snoRNA) 在致癌过程中的调节作用。本研究旨在分析HCC中snoRNA SNORA52的表达，探讨其表达与HCC患者各种临床特征的相关性。通过使用定量实时PCR，我们发现SNORA52在HCC细胞系（P < 0.05）和HCC组织（P < 0.001）中下调。相关分析显示，SNORA52的表达与肿瘤大小（P=0.011）、病灶数量（P=0.007）、包膜侵犯（P=0.011）、肿瘤分化程度（P=0.046）、TNM分期（P=0.004）显着相关。无病生存（DFS）和总生存（OS）分析显示，SNORA52表达较低的患者预后较差（P < 0.001）。单变量和多变量Cox回归分析显示，SNORA52表达是预测HCC患者DFS（P = 0.009）和OS（P = 0.012）的完全独立的预后因素。总体而言，我们的研究结果表明，SNORA52 表达水平在 HCC 组织中下调，并与多个临床变量相关，并且 SNORA52 是 HCC 患者的独立预后因素，这表明 SNORA52 可以作为 HCC 患者的潜在诊断和预后生物标志物。
Hepatocellular carcinoma (HCC) is one of the most common and aggressive tumors in the world while the accuracy of the present tests for detecting HCC is poor. A novel diagnostic and prognostic biomarker for HCC is urgently needed. Overwhelming evidence has demonstrated the regulatory roles of small nucleolar RNA (snoRNA) in carcinogenesis. This study is aimed at analyzing the expression of a snoRNA, SNORA52, in HCC and exploring the correlation between its expression and various clinical characteristics of HCC patients. By using quantitative real-time PCR, we found that SNORA52 was downregulated in HCC cell lines (P < 0.05) and HCC tissues (P < 0.001). Correlation analysis showed that the expression of SNORA52 was obviously associated with tumor size (P = 0.011), lesion number (P = 0.007), capsular invasion (P = 0.011), tumor differentiation degree (P = 0.046), and TNM stage (P = 0.004). The disease-free survival (DFS) and overall survival (OS) analysis showed that patients with lower SNORA52 expression had a worse prognosis (P < 0.001). Univariate and multivariate Cox regression analysis showed that SNORA52 expression was a completely independent prognostic factor to predict DFS (P = 0.009) and OS (P = 0.012) of HCC patients. Overall, our findings showed SNORA52 expression levels were downregulated in HCC tissues and correlated with multiple clinical variables, and SNORA52 was an independent prognostic factor for HCC patients, which suggested that SNORA52 could function as a potential diagnostic and prognostic biomarker for HCC patients.
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DOI：
10.1038/nrc.2017.99
发表时间：
2018-01
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Anastasiadou E;Jacob LS;Slack FJ
通讯作者：
Slack FJ
影响因子：
5.9
作者：
Dong, Xue-Yuan;Guo, Peng;Boyd, Jeff;Sun, Xiaodong;Li, Qunna;Zhou, Wei;Dong, Jin-Tang
通讯作者：
Dong, Jin-Tang
DOI：
10.1093/jnci/djx030
发表时间：
2017-09-01
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Jemal A;Ward EM;Johnson CJ;Cronin KA;Ma J;Ryerson B;Mariotto A;Lake AJ;Wilson R;Sherman RL;Anderson RN;Henley SJ;Kohler BA;Penberthy L;Feuer EJ;Weir HK
通讯作者：
Weir HK
影响因子：
29.4
作者：
Villanueva A;Hoshida Y;Battiston C;Tovar V;Sia D;Alsinet C;Cornella H;Liberzon A;Kobayashi M;Kumada H;Thung SN;Bruix J;Newell P;April C;Fan JB;Roayaie S;Mazzaferro V;Schwartz ME;Llovet JM
通讯作者：
Llovet JM
影响因子：
7.4
作者：
Schulten HJ;Bangash M;Karim S;Dallol A;Hussein D;Merdad A;Al-Thoubaity FK;Al-Maghrabi J;Jamal A;Al-Ghamdi F;Choudhry H;Baeesa SS;Chaudhary AG;Al-Qahtani MH
通讯作者：
Al-Qahtani MH