Population-based human papillomavirus prevalence in Lampang and Songkla, Thailand
Population-based human papillomavirus prevalence in Lampang and Songkla, Thailand
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DOI：
10.1086/373901
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发表时间：
2003-04-15
影响因子：
6.4
通讯作者：
Herrero, R
中科院分区：
文献类型：
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作者：
Sukvirach, S;Smith, JS;Herrero, R
为了调查人乳头瘤病毒（HPV）感染的流行率和决定因素，宫颈癌的主要原因，我们研究了来自泰国南邦和宋卡的1741名大于或等于15岁的妇女。收集宫颈脱落细胞进行巴氏涂片筛查和36种不同HPV类型的DNA检测。采用酶联免疫吸附试验检测血清中抗HPV-16、-18、-31、-33和-58的L1病毒样颗粒（抗VLP）的IgG抗体。总体而言，110名女性（6.3%）HPV DNA阳性;最常见的类型是HPV-16，-52和-72。来自南邦的1035名妇女的HPV DNA年龄标准化患病率（9.1%; 95%置信区间[CI]，7.1-11.1）高于来自宋卡的706名妇女（3.9%; 95% CI，2.3%-5.6%）。所有妇女中有21.8%发现抗VLP抗体，南邦妇女（29.2%）比宋卡妇女（10.9%）更常见。宫颈HPV DNA的主要危险因素是年龄
To investigate the prevalence and determinants of human papillomavirus (HPV) infection, the primary cause of cervical cancer, we studied 1741 women greater than or equal to15 years of age from Lampang and Songkla, Thailand. Exfoliated cervical cells were collected for Papanicolaou smear screening and DNA detection of 36 different HPV types. Serum immunoglobulin G antibodies against L1 virus-like particles (anti-VLPs) of HPV-16, -18, -31, -33, and -58 were evaluated using enzyme-linked immunosorbent assay. Overall, 110 women (6.3%) were HPV DNA positive; the most common types were HPV-16, -52, and -72. The age-standardized prevalence of HPV DNA was higher among the 1035 women from Lampang (9.1%; 95% confidence interval [CI], 7.1-11.1) than among the 706 women from Songkla (3.9%; 95% CI, 2.3%-5.6%). Anti-VLPs were found in 21.8% of all women and were more frequent among women from Lampang (29.2%) than among women from Songkla (10.9%). Major risk factors for cervical HPV DNA were age