Effect of oleic acid on canine gastroduodenal motility, pyloric diameter and gastric emptying.
Effect of oleic acid on canine gastroduodenal motility, pyloric diameter and gastric emptying.
复制标题
油酸对犬胃十二指肠运动、幽门直径和胃排空的影响。
DOI：
--
复制
发表时间：
1983
影响因子：
--
通讯作者：
H. Ehrlein
中科院分区：
文献类型：
--
作者：
O. Keinke;H. Ehrlein
在清醒的比格犬中，用应变传感器和感应线圈记录胃窦、十二指肠和幽门的运动。研究了油酸对消化间期和排空土豆泥时胃十二指肠运动和幽门直径的影响。荧光镜下观察动脉血流量。通过不透射线的胃轮廓的面积测量法测量胃排空。十二指肠内注射油酸可缩小空腹时幽门的直径。在消化状态下，油酸减少了马铃薯粉的胃排空。胃窦运动明显减弱（振幅为100 +/- 39.2至93 +/- 41.2 mV，收缩频率为4.3 +/- 0.6至3.8 +/- 1.5 min-1，运动指数为435 +/- 197至345 +/- 213 V，n = 3400-4700次收缩），而十二指肠运动增强（振幅从100 +/- 49.6到106 +/- 58.6 mV，运动指数从548 +/- 296到567 +/- 377 V，n = 5800-6400收缩）。与对照餐相比，在松弛阶段期间幽门开口的直径小约25%。胃窦收缩减弱和幽门开口减少，胃排空减少，胃食糜后移增强。节段性十二指肠收缩的发生率越高，转移速度越慢。结果表明，胃排空受多种因素的共同调控。幽门通过在其松弛阶段产生不同的流动阻力而参与。
The motility of the antrum, duodenum and pylorus was recorded with strain gauge transducers and induction coils in conscious beagle dogs. The effect of oleic acid on gastroduodenal motility and on the pyloric diameter was studied in the interdigestive state and during emptying of a mashed potato meal. The flow of digesta was observed fluoroscopically. Gastric emptying was measured by planimetry of the radiopaque gastric silhouette. The intraduodenal injection of oleic acid reduced the diameter of the pylorus in the empty stomach. In the digestive state oleic acid diminished gastric emptying of the potato meal. The antral motility was significantly diminished (amplitudes from 100 +/- 39.2 to 93 +/- 41.2 mV, contractile frequency from 4.3 +/- 0.6 to 3.8 +/- 1.5 min-1, motility index from 435 +/- 197 to 345 +/- 213 V, n = 3400-4700 contractions), whereas the duodenal motility was enhanced (amplitudes from 100 +/- 49.6 to 106 +/- 58.6 mV, motility index from 548 +/- 296 to 567 +/- 377 V, n = 5800-6400 contractions). The diameter of the pyloric opening during the phase of relaxation was about 25% less in comparison to the control meal. The weaker antral contractions and the less opening of the pylorus diminished gastric evacuation and enhanced retropulsion of the gastric chyme. A higher incidence of segmental duodenal contractions produced a slower transfer of digesta. Results demonstrated that gastric emptying was regulated by several co-operating factors. The pylorus was involved by producing different resistances to flow during its phase of relaxation.