Pathogenesis of bronchopulmonary dysplasia: when inflammation meets organ development.
Pathogenesis of bronchopulmonary dysplasia: when inflammation meets organ development.
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DOI：
10.1186/s40348-016-0051-9
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发表时间：
2016-12
期刊：
影响因子：
--
通讯作者：
Ehrhardt H
中科院分区：
文献类型：
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作者：
Shahzad T;Radajewski S;Chao CM;Bellusci S;Ehrhardt H
支气管肺发育不良是一种早产儿慢性肺部疾病。它是由肺生理性发育障碍引起的，主要发生在球囊期，终生肺功能受限，并增加躯体和精神运动发育异常的风险。这种疾病的成因是多因素的，有产前和产后的起源。支气管肺发病机制的核心是机械通气和氧毒性引起的大量肺部炎症反应的诱导。促炎反应的程度以及对肺泡生长和血管生成的干扰程度差异很大，可以通过产前感染、产前类固醇和表面活性剂的应用来改变。这篇综述总结了最近在患者队列和实验模型中获得的关于肺部炎症反应的重要研究成果。不幸的是，最近基于这些发现的临床实践变化对支气管肺发育不良的发生率影响有限。
Bronchopulmonary dysplasia is a chronic lung disease of preterm infants. It is caused by the disturbance of physiologic lung development mainly in the saccular stage with lifelong restrictions of pulmonary function and an increased risk of abnormal somatic and psychomotor development. The contributors to this disease’s entity are multifactorial with pre- and postnatal origin. Central to the pathogenesis of bronchopulmonary is the induction of a massive pulmonary inflammatory response due to mechanical ventilation and oxygen toxicity. The extent of the pro-inflammatory reaction and the disturbance of further alveolar growth and vasculogenesis vary largely and can be modified by prenatal infections, antenatal steroids, and surfactant application. This minireview summarizes the important recent research findings on the pulmonary inflammatory reaction obtained in patient cohorts and in experimental models. Unfortunately, recent changes in clinical practice based on these findings had only limited impact on the incidence of bronchopulmonary dysplasia.