Prostate Stem Cells and Cancer Stem Cells
Prostate Stem Cells and Cancer Stem Cells
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前列腺干细胞和癌症干细胞
DOI：
10.1101/cshperspect.a030395
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发表时间：
2019-06-01
影响因子：
5.4
通讯作者：
Shen, Michael M.
中科院分区：
文献类型：
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作者：
Li, Jia J.;Shen, Michael M.
茎/祖细胞在器官发生和组织维持过程中起着核心作用，而癌症干细胞（CSC）被认为促进了肿瘤恶性肿瘤。在这里，我们回顾了在基因工程小鼠模型以及人体组织中鉴定和分析正常前列腺茎/祖细胞以及推定的CSC方面的最新进展。我们还讨论了研究了前列腺癌的细胞来源类型的研究。此外，我们还对干细胞分析中使用的方法和大纲方向进行了批判性评估，以供将来研究。
Stem/progenitor cells play central roles in processes of organogenesis and tissue maintenance, whereas cancer stem cells (CSCs) are thought to drive tumor malignancy. Here, we review recent progress in the identification and analysis of normal prostate stem/progenitor cells as well as putative CSCs in both genetically engineered mouse models as well as in human tissue. We also discuss studies that have investigated the cell type of origin for prostate cancer. In addition, we provide a critical assessment of methodologies used in stem cell analyses and outline directions for future research.