A Versatile Octapod-Shaped Hollow Porous Manganese(II) Oxide Nanoplatform for Real-Time Visualization of Cargo Delivery.
A Versatile Octapod-Shaped Hollow Porous Manganese(II) Oxide Nanoplatform for Real-Time Visualization of Cargo Delivery.
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DOI：
10.1021/acs.nanolett.9b01900
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发表时间：
2019-07
期刊：
影响因子：
10.8
通讯作者：
Ruixue Wei;Xuanqing Gong;Hongyu Lin;Ke Zhang;Ao Li;Kun-hong Liu;H. Shan;Xiaoyuan Chen;Jinhao G
中科院分区：
文献类型：
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作者：
Ruixue Wei;Xuanqing Gong;Hongyu Lin;Ke Zhang;Ao Li;Kun-hong Liu;H. Shan;Xiaoyuan Chen;Jinhao G
多功能纳米平台具有良好的性能，包括优异的装载效率，实时监测，以及改善货物的生物利用度和生物选择性是在生物医学研究界的巨大需求。在纳米平台的发展过程中，刺激响应纳米颗粒（NPs）作为一种智能纳米平台最近受到了广泛的关注。在此，我们报告了小尺寸的八脚形中空多孔锰（II）氧化物（HPMO）纳米颗粒作为刺激响应T1-活化的纳米平台，用于肿瘤特异性货物递送和实时监测。通过两性离子多巴胺磺酸盐（ZDS）功能化的HPMO NPs可以作为一个通用的平台，以高负载效率负载有机染料或化疗药物。所获得的Cargo@HPMO在弱酸性条件下，特别是在肿瘤微环境和溶酶体中，会分解成顺磁性Mn 2+离子，随后释放出货物。释放的Mn 2+可以增强T1磁共振信号，用于实时监测体内货物递送。这种八角形Cargo@HPMO可以作为一种智能和多功能的纳米平台，具有pH响应的多模式成像和位点特异性药物递送，用于开发癌症的准确诊断和有效治疗。
Multifunctional nanoplatforms featuring promising properties including excellent loading efficiency, real-time monitoring, and improved cargo bioavailability and bioselectivity are in great demand by the biomedical research community. During the development of such nanoplatforms, stimuli-responsive nanoparticles (NPs) as a smart nanoplatform have recently received extensive attention. Herein, we report small-sized octapod-shaped hollow porous manganese(II) oxide (HPMO) NPs as a stimuli-responsive T1-activatable nanoplatform for tumor-specific cargo delivery and real-time monitoring. The HPMO NPs functionalized by zwitterionic dopamine sulfonate (ZDS) can act as a versatile platform to load organic dyes or chemotherapeutic drugs with high loading efficiency. The obtained Cargo@HPMO would decompose into paramagnetic Mn2+ ions and subsequently release cargoes in mild acidic conditions, especially in tumor microenvironment and lysosome. The released Mn2+ can enhance T1 magnetic resonance signal for real-time monitoring of the cargo delivery in vivo. This octapod-shaped Cargo@HPMO can act as a smart and versatile nanoplatform with pH-responsive multimodal imaging and site-specific drug delivery for the development of accurate diagnosis and effective therapy for cancer.