Gating valve on spinning microfluidic platforms: A flow switch/control concept
Gating valve on spinning microfluidic platforms: A flow switch/control concept
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DOI：
10.1016/j.snb.2014.07.097
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发表时间：
2014-12-01
影响因子：
8.4
通讯作者：
Madou, Marc J.
中科院分区：
文献类型：
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作者：
Kazemzadeh, Amin;Ganesan, P.;Madou, Marc J.
旋转微流控平台上的流动切换，通常基于科里奥利力，可以实现更复杂和灵活的分析序列，如混合、计量、高质量DNA的制备和操作等。到目前为止，离心式微流控平台上的流量切换技术是通过改变旋转方向或利用外部动力源，例如气动或热气动压力来实现的。我们设计了一种浇注微结构，它可以控制离心微流体中的流动方向，而不需要改变圆盘旋转的方向，也不需要进行表面处理或使用外部源。该装置是一种频率相关的阀，它能够在低频下将水流引向一个方向(例如，CW)，在较高频率下将水流引向相反的方向(例如，CCW)。在低频下，由于特殊的浇注组织，液体遵循微路径，而在高频下，液体遵循科里奥利力的方向。通过实验和数值模拟研究了这种新型阀门对二元水和不同物化性质液体的流动行为。结果表明，该新型阀门能够控制旋转式微流控平台上各种物化性质液体的流动方向。(C)2014爱思唯尔B.V.保留所有权利。
Flow switching on spinning microfluidic platforms, i.e., usually based on Coriolis force enables more sophisticated and flexible assay sequences such as mixing, metering, preparation and manipulation of high quality DNA and so on. Thus far flow switching techniques on centrifugal microfluidic platforms have been accomplished by changing the spinning direction or by exploiting external power sources, e.g., pneumatic or thermo pneumatic pressure. We have devised a gating microstructure that controls the flow direction in centrifugal microfluidics without the need of changing the direction of the disc rotation, applying surface treatments or employing external sources. The device is a frequency dependent valve that is able to direct the flow to one direction (e.g., cw) at low frequency and to the opposite direction (e.g., ccw) at higher frequencies. At low frequencies the liquid follows a micropath as a consequence of the specific gating microstructure and at higher frequencies liquid follows the direction of the Coriolis force. The flow behavior of the new valve for di water as well as liquids with different physicochemical properties has been investigated experimentally and numerically. The results show that the new valve is able to control the flow direction on spinning microfluidic platforms for liquids of the wide range of physicochemical properties. (C) 2014 Elsevier B.V. All rights reserved.