Measuring retinal contributions to the optical Stiles-Crawford effect with optical coherence tomography
Measuring retinal contributions to the optical Stiles-Crawford effect with optical coherence tomography
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DOI：
10.1364/oe.16.006486
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发表时间：
2008-04-28
期刊：
影响因子：
3.8
通讯作者：
Miller, Donald T.
中科院分区：
文献类型：
--
作者：
Gao, Weihua;Cense, Barry;Miller, Donald T.
视网膜反射的方向性成分，即光学斯泰尔斯-克劳福德效应(SCE)，是由光感受器的波导性引起的。然而，对于哪些视网膜反射被波导并因此起作用，仍然存在相当大的不确定性。为此，我们开发了一种基于光谱域光学相干层析成像(SD-OCT)的视网膜相机，它可以轴向分辨(类似于5微米)这些反射，并允许在近红外波长直接研究SCE的起源。光感受器内外节段交界处(IS/OS)和外节后端(PTO)的反射对入射位置高度敏感，随着光圈偏心的增加，亮度显著降低。视网膜色素上皮(RPE)的反射在很大程度上是不敏感的。四个受试者在IS/OS、PTOS和RPE偏心2度时的平均方向性(Rho(OCT)值)分别为0.120、0.270和0.016 mm(-2)。IS/OS的方向性接近于典型的心理物理SCE测量，而PTOS的方向性接近于传统的光学SCE测量。研究发现，精确测量光学姐妹互换需要显著的A扫描平均。(C)2008年美国光学学会。
The directional component of the retinal reflection, i. e., the optical Stiles-Crawford effect (SCE), is well established to result from the waveguiding property of photoreceptors. Considerable uncertainty, however, remains as to which retinal reflections are waveguided and thus contribute. To this end we have developed a retina camera based on spectral-domain optical coherence tomography (SD-OCT) that axially resolves (similar to 5 mu m) these reflections and permits a direct investigation of the SCE origin at near infrared wavelengths. Reflections from the photoreceptor inner/outer segments junction (IS/OS) and near the posterior tip of the outer segments (PTOS) were found highly sensitive to beam entry position in the pupil with a considerable decrease in brightness occurring with an increase in aperture eccentricity. Reflections from the retinal pigment epithelium (RPE) were largely insensitive. The average directionality (rho(oct) value) at 2 degree eccentricity across the four subjects for the IS/OS, PTOS, and RPE were 0.120, 0.270, and 0.016 mm(-2), respectively. The directionality for the IS/OS approached typical psychophysical SCE measurements, while that for the PTOS approached conventional optical SCE measurements. Precise measurement of the optical SCE was found to require significant A-scan averaging. (C) 2008 Optical Society of America.