Effects of α-pompilidotoxin on synchronized firing in networks of rat cortical neurons
Effects of α-pompilidotoxin on synchronized firing in networks of rat cortical neurons
复制标题
α-pompilidotoxin 对大鼠皮质神经元网络同步放电的影响
DOI：
10.1016/s0304-3940(98)00555-2
复制
发表时间：
1998
影响因子：
2.5
通讯作者：
H. Robinson
中科院分区：
文献类型：
--
作者：
A. Harsch;K. Konno;H. Takayama;N. Kawai;H. Robinson
我们研究了一种新型神经毒素 α-pomilidotoxin (α-PMTX) 对培养的大鼠皮层神经元自发同步网络放电的影响。 α-PMTX 立即且不可逆地破坏同步活动，仅留下残留的稀疏、不相关的放电，并且在 10 nM 的浓度下有效。在存在荷包牡丹碱来阻断抑制性突触传递的情况下，同步活动的关闭发生显着延迟，需要更高浓度的 α-PMTX (>100 nM)，并且之前的放电水平短暂增加。 α-PMTX 似乎会放大抑制性和兴奋性神经元活动或突触传递，但强烈的活动最终会导致失活或递质耗竭。
We studied the effect of a novel neurotoxin, α-pompilidotoxin (α-PMTX) on the spontaneously synchronized network firing of cultured rat cortical neurons. α-PMTX acted immediately and irreversibly to disrupt synchronous activity, leaving only residual sparse, uncorrelated firing and was effective at concentrations of 10 nM. In the presence of bicuculline to block inhibitory synaptic transmission, the shutdown in synchronized activity occurred with a significant delay, required a higher concentration of α-PMTX (>100 nM), and was preceded by a transiently increased level of firing. It appears that both inhibitory and excitatory neuronal activity or synaptic transmission are amplified by α-PMTX, but that intense activity eventually leads to inactivation or transmitter depletion.
Omega-agatoxins：来自漏斗网蜘蛛（Agelenopsis aperta）毒液的两种亚型的新型钙通道拮抗剂。
DOI：
--
发表时间：
1990
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Adams,ME;Bindokas,VP;Hasegawa,L;Venema,VJ
通讯作者：
Venema,VJ