Maternal Leptin Predicts Adiposity of the Neonate
Maternal Leptin Predicts Adiposity of the Neonate
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DOI：
10.1159/000355387
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发表时间：
2014-01-01
影响因子：
3.2
通讯作者：
Metzger, Boyd E.
中科院分区：
文献类型：
--
作者：
Josefson, Jami L.;Zeiss, Dinah M.;Metzger, Boyd E.
背景：出生时肥胖增加可能识别出婴儿发展为肥胖的高危人群。母亲肥胖和妊娠期高血糖与新生儿肥胖增加有关；然而，导致新生儿肥胖增加的母亲肥胖特征需要进一步研究。目的：测量非妊娠期糖尿病的肥胖和正常体重妇女的新生儿的肥胖度，以检验肥胖妇女的新生儿与正常体重妇女的新生儿相比肥胖程度增加的假设。方法：61名体重指数正常或肥胖的孕妇和她们的新生儿参加了在学术医学中心进行的这项横断面研究。新生儿肥胖，以体脂百分比(脂肪质量/身体质量)表示，用空气置换体积描记仪测量，脐带血进行生物标志物分析。结果：肥胖母亲和正常体重母亲的新生儿肥胖没有差别。根据瘦素水平对母亲进行分层显示，瘦素水平较高的母亲所生的新生儿肥胖率显著更高(13.2vs.11.1%，p=0.035)。在整个队列中，肥胖与脐带血瘦素(r=0.48，p<；0.001)和脂联素(r=0.27，p=0.04)水平呈正相关。结论：正常血糖孕妇的肥胖与新生儿肥胖症的增加无关。高水平的母体瘦素可识别肥胖增加的新生儿。(C)2013年S.Karger AG，巴塞尔
Background: Increased adiposity at birth may identify infants at high risk of developing obesity. Maternal obesity and hyperglycemia in pregnancy are associated with increased neonatal adiposity; however, features of maternal obesity that contribute to increased neonatal adiposity need further study. Aims: To measure adiposity in neonates of obese and normal-weight women without gestational diabetes to test the hypothesis that obese women have neonates with increased adiposity compared to neonates of normal-weight women. Methods: Sixty-one pregnant women, with a normal or obese BMI, and their neonates participated in this cross-sectional study at an academic medical center. Neonatal adiposity, expressed as percent body fat (fat mass/body mass), was measured by air displacement plethysmography and cord blood was assayed for biomarkers. Results: Adiposity in neonates of obese and normal-weight mothers did not differ. Stratifying mothers by leptin level showed that neonates born to mothers with higher leptin had significantly higher adiposity (13.2 vs. 11.1%, p = 0.035). In the entire cohort, adiposity positively correlated with cord blood leptin (r = 0.48, p < 0.001) and adiponectin (r = 0.27, p = 0.04) levels. Conclusion: Obesity in normoglycemic pregnant women was not associated with increased neonatal adiposity. High maternal leptin levels identified neonates with increased adiposity. (C) 2013 S. Karger AG, Basel