Assessment of early therapy response with 18F-FLT PET in glioblastoma multiforme.

Assessment of early therapy response with 18F-FLT PET in glioblastoma multiforme.
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使用 18F-FLT PET 评估多形性胶质母细胞瘤的早期治疗反应。

DOI:
10.1097/rlu.0000000000000321
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发表时间:
2014
影响因子:
10.6
通讯作者:
Mountz,JamesM
Mountz,JamesM
中科院分区:
医学3区
文献类型:
--
作者:
Oborski,MatthewJ;Demirci,Emre;Laymon,CharlesM;Lieberman,FrankS;Mountz,JamesM

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多形性胶质母细胞瘤的早期治疗反应评估仍然是一个挑战。MRI评估依赖于肿瘤对比度增强或大小的变化,这些变化在早期治疗反应评估时间通常不可见。此外,如果仅发生分子变化,则MRI对于早期治疗反应评估可能不可靠。PET与18 F-FLT(一种与细胞增殖相关的示踪剂)已被提议作为早期治疗反应评估的潜在方法,并且是一个活跃的研究领域。我们介绍了一个病例,其中18 F-FLT PET的早期反应评估与1年随访结果良好相关。
Early therapy response assessment in glioblastoma multiforme remains a challenge. Evaluation by MRI relies on changes in tumor contrast enhancement or size, which are usually not visible at early therapy response assessment times. In addition, MRI may not be reliable for early therapy response assessment if only molecular changes have occurred. PET with 18 F-FLT, a tracer associated with cellular proliferation, has been proposed as a potential method of early therapy response assessment and is an area of active research. We present a case where early response assessment with 18 F-FLT PET was associated with a favorable 1-year follow-up outcome.
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